what is mathematical biology and how useful is it.ppt

virus particles radial velocity (5) (6) (7) Tumor Radius b large infected (uninfected ) immune and kills infected and virus - then: immune cells kill themselves immune In the meantime uninfected cells Remaining virus renew attack infected Conclusions OV hrR3 cannot eradicate glioma. If however b can be increased to ≥ 150 then the radius will shrink and become very small (even without CPA) CPA will help a little bit in decreasing the radius, but its primary effect is decreasing the density of uninfected tumor cells – thus reducing the risk of secondary tumor. Protocols of CPA treatment (weekly, or double-dose biweekly) do not make a significant difference. Problem Provide vigorous mathematical proof to the numerical results. This lecture was found through National Academy of Sciences (NAS) Lecture Links /~super1/Science/nasmembers.htm Avner FriedmanDistinguished University Professor Director, Mathematical Biosciences InstituteThe Ohio State University (PhD, Hebrew University) /~afriedman/ * What is Mathematical Biology and how useful is it? Avner Friedman What is life? What is mathematical biology? Wound healing Hemodialysis Tuberculosis (aging) Glioblastoma What is life? Unit of life is a cell. Processes of living. (according to F. Harold, “The Way of the Cell,” 2001) Flux of matter and energy Chemical activities: absorb nutrients, produce biomass, eliminate waste products Adaptation Structure and function evolve to promote organism survival Organization A bacterial cell consists of 300 million molecules, assembled non-randomly DNA ? RNA ? Protein is strategically planned and executed Self-reproduction Autonomously, not by external forces What is Mathematical Biology? Talking to biologists and getting familiar with their experiments and data with respect to a biological process. Developing a mathematical model that describes the biological process (e.g., by differential equations)