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2016-03-06 发布于山东
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effect of aqueous extract of phaseolus vulgaris stronglstrong. (red kidney.pdf

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effect of aqueous extract of phaseolus vulgaris stronglstrong. (red kidney

Luka CDet al., IJSIT, 2013, 2(4),292-301 EFFECT OF AQUEOUS EXTRACT OF PHASEOLUS VULGARIS L. (RED KIDNEY BEANS) ON ALLOXAN-INDUCED DIABETIC WISTAR RATS Luka CD*, Olatunde A, Tijjani H and Olisa-Enewe IA Department of Biochemistry, Faculty of Medical Sciences, University of Jos, Plateau State, Nigeria ABSTRACT Aqueous extract of Phaseolus Vulgaris L. (Red Kidney Beans) was investigated for its effects in alloxan induced-diabetic rats. Twenty four albino rats were randomly allocated into four groups (A-D) of six rats each such that group A (diabetes control) received 0.5 mL distilled water, group B (diabetes) received 400 mg/kg bwt of extract, group C (normal control) received 0.5 mL of distilled water while group D (normal) received 400 mg/kg bwt of extract, all extract were orally administered once daily for 14 days. Diabetes was induced in groups AB by single interperitonial injection of 150 mg/kg alloxan monohydrate. Phytochemical screening indicated the presence of alkaloids, balsam, flavonoids, saponins, tannins, cyanogenic glycosides, terpenes and steroids. The hypoglyceamic potential of Phasoelus vulgaris L. was expressed in diabetes treated rats. Blood glucose, total protein, albumin and cholesterol levels of the diabetes treated rats and normal treated rats were not significantly (p0.05) altered when compared with the control rats. However, these values were significantly (p0.05) increased in diabetes untreated rats. Aqueous extracts of Phaseolus vulgaris L. at 400 mg/kg body weight also significantly reduce (p0.05) the values of ALT, AST and ALP when compared to high values of the enzymes observed in diabetes untreated rats. Extract had no significant (p0.05) effects on PCV and Hb in all groups when c