原创力文档a review of demineralized bone matrices for spinal fusion the evidence for efficacy：回顾脱钙骨基质的脊柱融合效果的证据.pdfVIP
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a review of demineralized bone matrices for spinal fusion the evidence for efficacy：回顾脱钙骨基质的脊柱融合效果的证据
t h e s u r g e o n 1 1 ( 2 0 1 3 ) 3 9 e4 8
Available online at
The Surgeon, Journal of the Royal Colleges
of Surgeons of Edinburgh and Ireland
Review
A review of demineralized bone matrices for spinal fusion:
The evidence for efficacy5
B. Aghdasi*, S.R. Montgomery, M.D. Daubs, J.C. Wang
Department of Orthopaedic Surgery, University of California at Los Angeles, Los Angeles, CA, USA
a r t i c l e i n f o a b s t r a c t
Article history: Background and purpose: Autologous Iliac Crest Bone Grafting (ICBG) is considered the
Received 20 March 2012 gold-standard graft choice for spinal arthrodesis; however, it is associated with donor site
Received in revised form morbidity and a limited graft supply. Bone graft alternatives to replace autograft and
11 June 2012 augment arthrodesis are a topic of ongoing research. This article will review properties of
Accepted 24 August 2012 Demineralized Bone Matrix (DBM) and review the evidence for its use, including animal
Available online 3 October 2012 models and human clinical trials.
Methods: A systematic and critical review of the English-language literature was conducted
Keywords: on Pubmed, Cochrane, CINAHL, and Google Scholar using search key terms such as
Demineralized bone matrix ‘Demineralized Bone Matrix’, ‘Spine’ and ‘Fusion’. Papers that were included were original
Bone graft research articles in peer-reviewed journals that investigated
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