a review of fluorescent ligands for studying 5-ht3 receptors：研究综述的5-ht3受体的配体的荧光.pdfVIP

Neuropharmacology xxx (2015) 1e10 Contents lists available at ScienceDirect Neuropharmacology journal homepage: /locate/neuropharm Invited review A review of fluorescent ligands for studying 5-HT3 receptors Martin Lochner a, *, Andrew J. Thompson b, ** a Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland b Department of Pharmacology, Tennis Court Road, Cambridge, CB2 1PD, UK a r t i c l e i n f o a b s t r a c t Article history: The use of fluorescence is a valuable and increasingly accessible means of probing the pharmacology and Available online xxx physiology of cells and their receptors. To date, the use of fluorescence-based methods for 5-HT3 receptor research has been quite limited and, although a variety of approaches have been described, these are Keywords: broadly distributed throughout the literature. In this review we condense these findings into a single, Fluorescent ligand accessible source of reference with the hope of promoting the use of these valuable molecular probes. 5-HT3 receptor This article is part of a Special Issue entitled ‘Fluorescent Neuro-Ligands’. Fluorescence polarisation © 2015 Elsevier Ltd. All rights reserved. Imaging Synthesis Flow cy