程序性细胞死亡与细胞衰老解析.pdf

第十三章 程序性细胞死亡与细胞衰老 Section 1: Programmed Cell Death (PCD) Cells are balanced between life and death DAMAGE Physiological death signals DEATH SIGNAL DEATH SIGNAL DDEEAATTHH SSIIGGNNAALL PROAPOPTOTIC ANTIAPOPTOTIC PROTEINS PROTEINS Apoptosis：细胞凋亡 Three ways of animal cell death Necrosis：细胞坏死 Autophagy：细胞自噬 PCD Versus Apoptosis Apoptosis History: 1965, Kerr, Observance; Definition in 1972 Conception: Apoptosis(Apo-ptosis), interchangeably with “programmed cell death”: The cells activate an intracellular death and kill themselves in a controlled way History of cell death / apoptosis research History of cell death / apoptosis research HHiissttoorryy ooff cceellll ddeeaatthh // aappooppttoossiiss rreesseeaarrcchh History of cell death / apoptosis research History of cell death / apoptosis research HHiissttoorryy ooff cceellll ddeeaatthh // aappooppttoossiiss rreesseeaarrcchh 1800s Numerous observation of cell death 1908 Mechnikov wins Nobel prize (phagocytosis) 1930-40 Studies of metamorphosis 1948-49 Cell death in chick limb exploration of NGF 1955 Beginning of studies of lysomes 1964-66 Necrosis PCD described 1971 Term apoptosis coined 1977 Cell death genes in C. elegans 1980-82 DNA ladder observed ced-3 identified 1989-91 Apoptosis genes identified, including bcl-2, fas/apo1 p53, ced-3 sequenced (Richerd et.al., 2001) Necrosis vs. Apop