纳米制剂.ppt

Stability of nano-preparation 纳米药物 nano-drug 定义 将药物的微粒或者将药物吸附包裹在特定载体中，制成纳米尺寸范围内的微粒，然后以其为基础制成不同种类的剂型。 Comparison Ethnodrug 药物微粒大、表面反应活性低、活性中心少、催化效率低、吸附能力弱，并且对人体的毒性较大，疗效却不佳，且存在严重的量效效应，即疗效—剂量依赖关系 Adhesiveness Change mechanism of membrane transport Controlled release：the use of carrier material, can slow dissolution The stability of nano-preparation Nanomedicine crystal stability is affected by many factors : formulation types dry powder, nano-suspension dispersion medium aqueous and non-aqueous route of administration oral, inhalation, intravenous injection , production technology "top-down" and "bottom-up" the nature of the drug itself small molecules and biological macromolecules 1.Formulations affect the stability Nano-drug are widely used in oral, eye, lung and skin delivery systems. They have same phenomenon of instability for different forms, such as precipitation, agglomeration and crystal growth, but these phenomenon have different effect on clinical. Moreover, the choice of stabilizer are also closely related to formulations. 2.The physical stability of nano-drug Stability of Nano-drug ：physical, chemical and biological stability sedimentation 物理化学 aggregation 的角度 crystal growth crystalline state change 2.1 Sedimentation Nano-drug generally have three kinds of precipitation: agglomeration, loose aggregates and open floc. Under the action of gravity, the process of particles directional movement and makes the dispersion happened phase separation is known as sedimentation. Stokes公式： V 2 r2（ρ1-ρ2） g/（9η） 式中，V 为微粒沉降速度，r 为微粒半径，ρ1、ρ2分别为微粒和分散介质的密度，g 为重力加速度，η为分散介质黏度。 V 2 r2（ρ1-ρ2） g/（9η） 由Stokes 公式可见，微粒沉降速度与微粒半径平方、微粒与分散介质的密度差成正比，与分散介质的黏度成反比。 Primary method of reducing nano-drug sedimentation ： ① Reduce particle radius ； ② Reducing the density difference between the solid particles and the dispersion medium ； ③ Increase the viscosity of the dispersion medium Flocculant In the flocculant, particle begins sedimentation in the form of