斯沃的强效与广谱分解.pptVIP

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* 金葡菌的致病因子。 . A, 表面和分泌的蛋白. B and C, Cross-sections of the cell envelope. TSST-1, toxic shock syndrome toxin 1. 毒性休克毒素综合征毒素-I * * Mastitis phagocytic * * Supplemental Information: Data from The Surveillance Network – USA (TSN), a database containing the results of over 105 million susceptibility tests from 300 US hospitals, shows that close to 60% of all S aureus isolates from hospital inpatients were MRSA1 Study design: Moran et al conducted a prospective surveillance study of 422 adults with CA SSSIs presenting to the emergency department in 11 US cities2 Sites: Albuquerque; Atlanta; Charlotte, NC; Kansas City, MO; Los Angeles; Minneapolis; New Orleans; New York; Philadelphia; Phoenix, AZ; Portland, OR References: 1. Styers D, et al. Ann Clin Microbiol Antimicrob. 2006;5:2. 2. Moran GJ, et al. N Engl J Med. 2006;355:666-674. Key Points: Hospital-based surveillance revealed that methicillin resistance is noted in the majority of S aureus strains across the country For SSTI patients presenting to the emergency department, methicillin-resistant strains accounted for 15% to 74% of all S aureus strains, with a national overall prevalence of 59% MRSA in the Hospital and in the Community * * MRSA is a big problems in our hospital. The prevalence of MRSA causing nosocomial infections increased from 20% to 40% in early 1990s to 80% in 2002. Although we have screened vancomycin resistance for more than five thousand isolates of MRSA, no VISA or VRSA or vancomycin hetero-resistance was found. Indeed, some strain of VISA confirmed by Professor Hiramatsu were found in other hospital in Taiwan. 要点:呼吸道感染是ICU患者发生脓毒血症最主要的原发病灶 一项来自于2001.7-2001-12对140例ICU住院患者共发生152例次脓毒血症的起源、致病菌的研究结果 呼吸道感染使ICU患者发生脓毒血症最主要的原发病灶,占49%,外科伤口感染占16% 参考文献 Mathur P,et al. Indian J Med Res. 2005;122:305-8 * * * * 利奈唑胺浓度越高,TNF因子的数量越少,有助于减少机体炎性反应。 * * * * 万古霉素MIC值越高,治疗失败率越高 Lodise TP et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2008;52(9):3315-3320. 死亡率(%) 平均时间(天) 24/66 4/26 12/66 3/26 P=0.049 P=0.5 P

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