2013-3-3文献讲解.ppt

Origin:Apoptosis (2010) 汇报人：翁碧霞 2013-03-10;Background;ACC(Adenoid cystic carcinoma):腺样囊性癌，是人类唾液腺中较常发生的恶性肿瘤。同样在乳腺，子宫颈以及气管支气管树等组织中也有发生。 这类肿瘤的组织结构有特异性（腺样【筛孔】型、管状型和实性【基底细胞样】型），长期预后不良，特别是高的复发率以及远处转移。 80%-90%的患者在诊断后10-15年内死亡，而且在过去的几十年中，手速切除并没有降低死亡率。 作者认为对于ACC治疗的难度大，预后差等原因是因为缺乏对肿瘤发生的分子机制的认知。;肿瘤细胞排列呈圆形、卵圆形或不规则形的上皮团块，其间含有大小不等的囊性腔隙，呈“筛孔”状，与藕的横断面相似;Experiment and result-- cyctotoxicity and induce apoptosis;Experiment and result-- cyctotoxicity and induce apoptosis;Experiment and result-- cyctotoxicity and induce apoptosis;机制图;Experiment and result-- quercetin is probably through a mitochondria-dependent pathway;Experiment and result-- quercetin is probably through a mitochondria-dependent pathway;Experiment and result-- quercetin is probably through a mitochondria-dependent pathway;Growth factor receptor;Experiment and result-- PI3K/Akt/IKK-a signaling axis;Experiment and result--nude mice xenografts model;Experiment and result--nude mice xenografts model;Experiment and result--Clinical samples;Experiment and result--Clinical samples;Experiment and result--PI3K特异性抑制剂 LY294002;Growth factor receptor;结论;Thank you