基于氧化石墨烯纳米微片的荧光生物传感器用于DNA单碱基错配的重点.doc

DNA Single-Base Mismatch Study Using Graphene Oxide Nanosheets-Based Fluorometric Biosensors 基于氧化石墨烯纳米微片的荧光生物传感器用于DNA单碱基错配的研究 ABSTRACT:Single nucleotide polymorphisms (SNPs) are frequently associated with various gene-related human diseases, whose determination has attracted great interest.?Herein, we report a graphene oxide (GO) nanosheets-based fluorometric DNA biosensor to study the type and location of the single-base mismatch, as well as the influence of the length of the strands.?The results indicated that both short and long targets led to much lower fluorescence signals than the perfec