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oncogene tumor suppressor gene
Department of Biochemistry and
molecular biology
Zhang Ying
OVERVIEW
Many genes and factors outside of genes is involved in carcinogenesis. The accumulation of many?genetic changes?cause cancer other than mutations?of a single?gene ?by?causing disorders ?of cell growth and differentiation, the?cell proliferation?out of control.?
Oncogene,?antioncogene,?tumor metastasis gene,?cell
apoptosis,?DNA damage and repair, telomerase, microRNA
Relationships of oncogene,?tumor suppressor gene?and growth factors
The regulation of gene expression and?cell proliferation, differentiation is involved in the mechanism of oncogenes?and tumor suppressor genes
Section I Oncogene
Concept of oncogene
Viral oncongene
Cellular oncogene
The products of oncongene and its fuction
一、the concept of oncogene?
Oncogene:the genes in cells is responsible of controlling cell?growth,?proliferation and differentiation. They will cause ?cellular?canceration?when their structure or expression turns abnormal.
All of genes which encode for growth factors, growth factor receptors, signal molecules and transcription factors related to growth.
The writing of oncogene
ras、src、mycv-rasc-ras
Classification of oncogene
1、virus oncogenes,v-onc: the genes existing in virus (mostly, retrovirus) which cause the target cells maligant transformation, such as v-src
2、Proto-oncogenes or cellular-oncogene, c-onc: the oncogenes existing in normal genome which are in quiescence or inactive state such as c-myc、c-ras、c-src。Under normal condition,these genes are in quiescence or low expression state and not only no harmful to cells but also helpful to stain normal function to cells.
The structural comparison of c-src and v-src
二、Virus oncogenesthe oncogene existing in virus genome which does not encode the protein of virurs and is not helpful to replication but do make host cell Continuous proliferation
Rous Peyto
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