癌基因与抑癌基因导论.ppt

  1. 1、本文档共108页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
oncogene tumor suppressor gene Department of Biochemistry and molecular biology Zhang Ying OVERVIEW Many genes and factors outside of genes is involved in carcinogenesis. The accumulation of many?genetic changes?cause cancer other than mutations?of a single?gene ?by?causing disorders ?of cell growth and differentiation, the?cell proliferation?out of control.? Oncogene,?antioncogene,?tumor metastasis gene,?cell apoptosis,?DNA damage and repair, telomerase, microRNA Relationships of oncogene,?tumor suppressor gene?and growth factors The regulation of gene expression and?cell proliferation, differentiation is involved in the mechanism of oncogenes?and tumor suppressor genes Section I Oncogene Concept of oncogene Viral oncongene Cellular oncogene The products of oncongene and its fuction 一、the concept of oncogene? Oncogene:the genes in cells is responsible of controlling cell?growth,?proliferation and differentiation. They will cause ?cellular?canceration?when their structure or expression turns abnormal. All of genes which encode for growth factors, growth factor receptors, signal molecules and transcription factors related to growth. The writing of oncogene ras、src、myc v-ras c-ras Classification of oncogene 1、virus oncogenes,v-onc: the genes existing in virus (mostly, retrovirus) which cause the target cells maligant transformation, such as v-src 2、Proto-oncogenes or cellular-oncogene, c-onc: the oncogenes existing in normal genome which are in quiescence or inactive state such as c-myc、c-ras、c-src。Under normal condition,these genes are in quiescence or low expression state and not only no harmful to cells but also helpful to stain normal function to cells. The structural comparison of c-src and v-src 二、Virus oncogenes the oncogene existing in virus genome which does not encode the protein of virurs and is not helpful to replication but do make host cell Continuous proliferation Rous Peyto

您可能关注的文档

文档评论(0)

***** + 关注
实名认证
内容提供者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档