脊髓固有电路结构和功能重组能促进脊髓损伤后的功能恢复.docVIP

脊髓固有电路结构和功能重组：能促进脊髓损伤后的功能恢复？ 成年中枢神经系统的轴突再生和再生纤维会受到限制，但过去几十年的研究已经发现脑和脊髓固有电路对更小损伤或去神经具有高适应和重组的能力。短距离纤维生长和突触重新布线被发现可发生在皮层，脑干和脊髓区域，并与损伤后引起的受损感觉运动功能恢复相关。这种结构性可塑性过程最初是在脊髓损伤或脑卒中后的皮质系统中的观察到的，但最近的研究表明，网状脊髓、红核脊髓或脊髓固有束同样具有极高的结构和功能重组能力。 发表于《中国神经再生研究（英文版）》杂志2015年4月第4期的文章中，瑞士苏黎世大学Linard Filli和Martin E. Schwab教授回顾了病变引起的脊髓固有途径的可塑性变化，他们认为，它们代表着不完全性脊髓损伤时触发感觉恢复的关键机制。脊柱迂回路径绕过周围病变部位的失神经脊髓上的命令组建或加强被认定为是诱导不同物种，从老鼠到灵长类动物神经基板大范围运动恢复的显著的神经基质。对当前的研究来说，仔细分析脊柱电路重构的生物学机制以及研究这些过程是如何通过治疗性干预措施（例如，纤维生长增强干预，康复措施）发挥其最佳功效是必须进行的调查。这方面的知识将为针对脊髓固有电路的显著可塑性开发新策略指明道路，并最大限度地提高脊髓损伤后的功能恢复。 Article: Structural and functional reorganization of propriospinal connections promotes functional recovery after spinal cord injury by Linard Filli1, Martin E. Schwab2 1 Laboratory for Sensorimotor Function, Department of Neurology, University Hospital Zurich, 8091 Zurich, Switzerland; 2 Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057, Zurich, Switzerland Filli L, Schwab ME 2015 Structural and functional reorganization of propriospinal connections promotes functional recovery after spinal cord injury. Neural Regen Res 10 4 :509-513. 欲获更多资讯： Structural and functional reorganization of propriospinal connections promotes functional recovery after spinal cord injury Axonal regeneration and fiber regrowth is limited in the adult central nervous system, but research over the last decades has revealed a high intrinsic capacity of brain and spinal cord circuits to adapt and reorganize after smaller injuries or denervation. Short-distance fiber growth and synaptic rewiring was found in cortex, brain stem and spinal cord and could be associated with restoration of sensorimotor functions that were impaired by the injury. Such processes of structural plasticity were initially observed in the corticospinal system following spinal injury or stroke, but recent studies showed an equally high potential for structural and functional reorganization in reticulospinal, rubro