组织工程化人工角膜的临床应用距离还有多远.docVIP

组织工程化人工角膜的临床应用：距离还有多远？ 陈佳佳，王文战，朱? 豫 郑州大学第一附属医院眼科，河南省郑州市? 450052 Clinical application of tissue-engineered keratoprosthesis Chen Jia-jia, Wang Wen-zhan, Zhu Yu Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China 摘要? 背景：人工角膜是取代混浊角膜组织而用异质成形材料制成的一种特殊屈光装置，通过手术植入患眼，以取得一定视力。目的：介绍近年来人工角膜研究进展。方法：由第一作者用计算机检索万方医学网和Medline database数据库，检索词分别为“人工角膜、角膜移植、生物相容性、组织工程”和“keratoprosthesis, corneal transplantation, biocompatibility, tissue engineering”，对人工角膜移植的动物实验、临床进展、植入方式及生物相容性、并发症等方面进行探讨。结果与结论：共检索到204篇文章，按纳入和排除标准对文献进行筛选，共纳入50篇文章。人工角膜的研制在近年来有了较大的进步，非组织工程化人工角膜在材料选择，处理和设计方式上有所创新，同时具有活性的组织工程化人工角膜的出现为人工角膜的研制开辟了一条新途径。 中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程 全文链接： 关键词?：?组织构建；?组织工程；?人工角膜；?角膜移植；?生物相容性； Abstract： BACKGROUND:?Keratoprosthesis is a special kind of refractive apparatus made of alloplasm shaping material, which is designed to replace the turbid cornea tissue. The visual acuity may be obtained after surgical implantation into the affected eyes.OBJECTIVE:?To introduce the advance of keratoprosthesis research.METHODS:?A computer-based online retrieval was performed among Wanfang and Medline databases, by using the key words of “keratoprosthesis, corneal transplantation, biocompatibility, tissue engineering” in English and Chinese. The animal experiment and clinical progress of artificial cornea transplantation, implantation and biocompatibility, complications were discussed.RESULTS AND CONCLUSION:?A total of 204 articles were selected, according to the inclusion and exclusion criteria, 50 articles were included in this study. People have made great progress in the research and production of keratoprosthesis within recent years. There are many new ideas in material choosing, handling and designing ways of non-tissue-engineered keratoprosthesis. Meanwhile, the appearance of active tissue-engineered keratoprosthesis created a new method for the research and production of keratopr