生物信息学资源与方法.pptVIP

2014.6 Objects Studied Genomics Genomic sequencing and mapping. Genome annotation (key issue is gene finding). Comparisons of multiple genomes. Transcriptomics Study of transcribed sequences, both of full-length cDNAs and ESTs (key issue is clustering of redundant sequences to coalesce all sequences that belongs to the same gene). Analysis of gene expression data (key issue is to find genes that are either up- or down-regulated under specific circumstances). Proteomics Analysis of protein sequences (key issue is discovering functional motifs that are conserved across evolution, and using