TACE序贯3D―CRT治疗原发性肝癌的疗效及安全性观察.docVIP

TACE序贯3D―CRT治疗原发性肝癌的疗效及安全性观察 　　【摘要】 目的 观察肝动脉化疗栓塞（TACE）序贯三维适形放疗（3D-CRT）治疗原发性肝癌的临床效果和安全性。方法 78例原发性肝癌患者， 按随机数字表法分为对照组与观察组， 各39例。对照组患者给予TACE序贯治疗；观察组患者在此基础上同时给予3D-CRT治疗。观察两组治疗效果， 并记录治疗期间不良反应发生情况。结果 观察组治疗总有效率82.1%高于对照组的61.5%（P0.05）， 骨髓抑制发生率48.7%低于对照组的71.8%（P0.05）。结论 TACE序贯3D-CRT治疗原发性肝癌能有效控制病情， 不良反应少， 疗效安全可靠。 　　【关键词】 肝动脉化疗栓塞；三维适形放疗；原发性肝癌 　　DOI：10.14163/j.cnki.11-5547/r.2016.13.008 　　Observation of curative effect and safety by sequential TACE and 3D-CRT in the treatment of primary liver cancer HOU Liang-xue. Department of Tumor Radiotherapy， Henan Shangqiu First People’s Hospital， Shangqiu 476100， China 　　【Abstract】 Objective To observe clinical effect and safety by sequential transhepatic arterial chemotherapy and embolization （TACE） and three dimensional conformal radiation therapy （3D-CRT） in the treatment of primary liver cancer. Methods A total of 78 patients with primary liver cancer were divided by random number table into control group and observation group， with 39 cases in each group. The control group received TACE for sequential therapy， and the observation group received additional 3D-CRT for treatment. Curative effects of the two groups were observed， and their adverse reactions were recorded. Results The observation group had higher total effective rate as 82.1% than 61.5% of the control group （P0.05）， and its incidence of myelosuppression was lower as 48.7% than 71.8% of the control group （P0.05）. Conclusion Sequential TACE and 3D-CRT can effectively control disease in treating primary liver cancer， along with few adverse reactions and creditable curative effect. 　　【Key words】 Transhepatic arterial chemotherapy and embolization； Three dimensional conformal radiation therapy； Primary liver cancer 　　原发性肝癌是我国发病率较高的一种恶性肿瘤， 多数确诊病例病情已发展至中晚期， 预后效果并不理想。针对此类患者， 手术治疗已无太大作用， 临床多主张进行非手术治疗。TACE是治疗原发性肝癌最为常见的一种非手术治疗方法， 可获得良好的近期效果， 但其远期效果较差， 毒副反应多[1]。3D-CRT治疗是一种高精度的放射治疗， 能精准照射病灶， 避免正常组织受影响。本文主要研究观察TACE序贯3D-CRT治疗原发性肝癌的临床效果和安全性， 现报告如下。 　　1 资料与方法 　　1. 1 一般资料 研究对象