T淋巴细胞亚群及微量元素与小儿反复呼吸道感染的关系.docVIP

T淋巴细胞亚群及微量元素与小儿反复呼吸道感染的关系 　　【摘要】 目的：探讨小儿反复呼吸道感染（RRTI）与T淋巴细胞亚群及微量元素之间的关系。方法：选取2013年12月-2015年1月来本院就诊的68例RRTI患儿为病例组，选取同期的68例健康儿童为对照组，采用流式细胞仪及原子吸收光谱法对两组儿童外周血T淋巴细胞亚群及全血微量元素进行检测及比较。结果：RRTI组儿童血锌、铁、钙、CD3+、CD4+及CD4+/CD8+均低于对照组，CD8+高于对照组，比较差异有同统计学意义（P0.05）。结论：RRTI患儿存在免疫功能失调，微量元素钙、铁、锌均有不同程度下降，并可能与患儿的发病、病情转归、预后有关，这些指标的变化可作为患病风险及评价疗效的参考指标。 　　【关键词】 T淋巴细胞亚群； 微量元素； 反复呼吸道感染 　　Correction between the T Lymphocyte Subsets， Trace Elements and Children with Recurrent Respiratory Tract Infection/JIAN Min， LI Jun-xin， LIU Chao.//Medical Innovation of China，2016，13（04）：061-064 　　【Abstract】 Objective： To explore the relationship between the trace elements， blood T lymphocyte subsets， and children with recurrent respiratory tract infection. Method： 68 children with recurrent respiratory tract infection from December 2013 to January 2015 in the hospital were chosen as observation group， and 68 healthy children at the same period were selected as control group. The level of blood trace elements and blood T lymphocyte subsets was detected and compared by atomic absorption spectrometry and flow cytometry between the two groups. Result： The zinc， ferrum， calcium， and CD3+， CD4+， CD4+/CD8+ of the observation group was significantly lower than that of the control group， while CD8+ was higher， with significant difference （P0.05）. Conclusion： Immune dysfunction can be observed in children with RRTI， trace elements such as calcium， ferrum， zinc decrease in varying degrees， which can be correlated with onset， outcome， and prognosis of children with RRTI， the changes of indexes can be used as reference indexes to evaluate curative effect. 　　【Key words】 T lymphocyte subsets； Trace elements； Recurrent respiratory tract infection 　　First-author’s address： Qingdao Women and Children’s Hospital， Qingdao 266034， China 　　doi：10.3969/j.issn.1674-4985.2016.04.018 　　反复呼吸道感染（Recurrent respiratory tract infection， RRTI）是儿科常见病、多发病，其病程长、病情反复难愈，易导致许多并发症，对患儿的生长发育和智力发育极为不利。其病因及发病机制尚未完全明确，除与先天性免疫缺陷和遗传因素有关外，目前认