培训课件_ACEI和ARB在慢性心衰中的应用.pptVIP

* Bradykinin and ACE inhibition Content Points: ? This study by Hornig and coworkers showed that ACE inhibition improves endothelial function by a bradykinin-dependent mechanism.11 In 10 healthy volunteers, they examined the effects of quinapril and the selective bradykinin antagonist icatibant and the 2 agents combined on resting tone and on flowdependent, endothelium-mediated dilation of the radial artery. ? Quinapril improved flow-dependent dilation of the radial artery by 46% over baseline compared with a 33% reduction with icatibant. This benefit was totally eliminated during infusion wit