肺癌组织中转运蛋白1的表达与肿瘤耐药的关系.docVIP

肺癌组织中糖转运蛋白1的表达与肿瘤耐药的关系 　　作者：赵焕芬,何春年,赵振彪,翟金萍,宋光耀　　作者单位：050051 石家庄市，河北省人民医院 　　【摘要】目的探讨肺癌组织中糖转运蛋白1(glucose transporter 1，GLUT1)、多药耐药相关蛋白(multidrug resistance related protein，MRP)和谷胱甘肽S转移酶-Π(glutathione S-transferase pi， GST-Π)的表达及其相关性。方法 采用免疫组织化学方法检测42例(其中男28例，女14例;平均年龄54.7岁。分型：小细胞癌2例，鳞癌21例，腺癌16例，细支气管肺泡癌3例)肺癌组织中GLUT1、MRP和GST-Π的表达。结果 42例肺癌组织中GLUT1阳性表达36例(85.7%);MRP阳性表达24例(57.1%);GST-Π阳性表达23例(54.8%)。GLUT1表达与GST-Π蛋白表达呈显著正相关性(P0.05)，与MRP表达无相关性(P0.05)。肺癌组织T3、T4与T1、T2相比GLUT1、MRP和GST-Π高表达率均明显增加，差异有统计学意义(P均0.05)。肺癌组织有淋巴结转移与无淋巴结转移相比，GLUT1、MRP和GST-Π高表达率均明显增加，差异有统计学意义(P均0.05)。结论 GLUT1在肺癌组织中高表达，并与GST-Π表达有显著正相关性;GLUT1可能对GST-Π的表达起上调作用。GLUT1、MRP和GST-Π高表达与肺癌的浸润程度和淋巴结转移有关。 　　【关键词】 肺癌;糖转运蛋白1;多药耐药相关蛋白;谷胱甘肽S转移酶-Π 　　The relationship between tumor drug resistance and expression of glucose transporter 1 in lung cancer 　　ZHAO Huanfen, HE Chunnian, ZHAO Zhenbiao,et al. 　　Hebei Provincial Peoples Hospital,Hebei,Shijiazhuang 050051 　　【Abstract】 Objective To investigate the expression of glucose transporter1 (GLUT1), multidrug resistance related protein(MRP) and glutathione S-transferase pi(GST-Π)in lung cancer.Methods The expression of GLUT1, MRP and GST-Π were tested by immunohistochemical method in 42 cases of lung cancer specimens including 28 males and 14 females, with an average age of 54.7. Among them 2 cases were small cell cancer, 21 cases squamous cancer,16 cases adenocarcinoma, and 3 cases bronchiolo-alveolar carcinoma.Results In 42 cases of lung cancer specimens, 36 cases showed positive staining of GLUT1 protein(85.7%); 24 cases showed positive staining of MRP protein(57.1%); 23 cases showed positive in GST-Π protein(54.8%). There was a significant positive correlation between the expression of GLUT1 and GST-Π(P0.05), but there was no significant correlation between GLUT1 and MRP(P0.05).As compared with the expression of GLUT1, MRP and GST-Πin lung cancer tissues of T1 and T2 group, there was significantly increased the T3 and T4 group (P0.05,P0.025,P0.01 r