10天序贯疗法与常规三联疗法根治幽门螺杆菌的效果探讨.docVIP

10天序贯疗法与常规三联疗法根治幽门螺杆菌的效果探讨 　　[摘要] 目的 探讨10天序贯疗法根治幽门螺杆菌的临床效果。 方法 选择80例患者，随机分为对照组与观察组各40例，对照组采用常规三联疗法，埃索美拉唑20 mg+克拉霉素0.5 g+阿莫西林1.0 g，观察组采用10天序贯疗法，前5天应用埃索美拉唑20 mg+阿莫西林1.0 g，后5天应用埃索美拉唑20 mg+克拉霉素0.5 g+替硝唑0.5 g，比较两组患者的幽门螺杆菌根治率及溃疡愈合率，并统计两组的临床疗效。 结果 观察组幽门螺杆菌根治率及溃疡愈合率均显著高于对照组（P0.05）；观察组治愈率高于对照组（P0.05），无效率低于对照组（P0.05）。 结论 10天序贯疗法根治幽门螺杆菌效果更显著，值得临床推广应用。 　　[关键词] 10天序贯疗法；常规三联疗法；根治；幽门螺杆菌 　　[中图分类号] R975 [文献标识码] A [文章编号] 1674-4721（2013）11（c）-0091-02 　　The effect of 10 days sequential therapy and conventional triple therapy for Helicobacter pylori 　　LUO Yu-xi 　　Jian People′s Hospital in Jiangxi Province，Jian 343100，China 　　[Abstract] Objective To investigate the effect of 10 days sequential therapy and conventional triple therapy for Helicobacter pylori.Methods 80 cases of patients were randomly divided into two groups，each 40 cases，the control group were used conventional triple therapy with esomeprazole 20 mg+clarithromycin 0.5 g+amoxicillin 1.0 g，the observation group were used sequential therapy with 10 days，in the first 5 days with esomeprazole 20 mg+amoxicillin 1.0 g，last 5 days were used esomeprazole 20 mg+tinidazole 0.5 g+clarithromycin 0.5 g，then patients with Helicobacter pylori cure rate， ulcer healing rate and clinical effects were compared in the two groups.Results The observation group with Helicobacter pylori cure rate and ulcer healing rate was significantly higher than that of control group （P0.05），the observation group with cure rate was higher than that of control group （P0.05），the no efficiency rate was significantly lower than that of control group （P0.05）.Conclusion The effect of 10 days sequential therapy for Helicobacter pylori is more pronounced，it is worthy of promotion. 　　[Key words] 10 days sequential therapy；Conventional triple therapy；Cure；Helicobacter pylori 　　目前幽门螺杆菌感染所发生的消化道溃疡呈现全球流行分布的趋势，因其感染后出现典型的高感染率的慢性严重尤其是胃和十二指肠等消化系统病变，而幽门螺杆菌能长期寄居在低pH值的胃黏膜细胞内，长期起到破坏胃黏膜细胞，导致胃和（或）十二指肠出现慢性溃疡甚至穿孔等炎症反应及并发症。有研究表明，幽门螺杆菌感染是引起胃癌的相关高危因素，因为幽门螺杆菌富含尿素酶，人体感染幽门螺杆菌后主要