丙戊酸钠对癫痫患儿体重的影响及作用机制.docVIP

丙戊酸钠对癫痫患儿体重的影响及作用机制 　　[摘要] 目的 研究丙戊酸钠（VPA）对癫痫患儿体重的影响及其机制。方法 按照纳入标准收集泸州医学院附属医院神经内科门诊2011年5月―2013年5月首次诊断癫痫后VPA单药治疗的患儿48例作为实验组，于治疗前、治疗后1、3、6个月检测患儿体质量指数（BMI）及血清瘦素水平。另选择健康儿童24例作为对照组。结果 实验组治疗后1、3、6个月BMI及血清瘦素均呈现出上升趋势，且两者在各时间点均明显高于对照组，差异有统计学意义（P0.05）。结论 VPA可增加癫痫患儿体重，其机制可能与显著上调血清瘦素水平有关。 　　[关键词] 丙戊酸钠；癫痫；瘦素 　　[中图分类号] R742.1 [文献标识码] A [文章编号] 1674-0742（2014）04（b）-0008-02 　　Effect of Valproic Acid Treatment on the Body Weight of Pediatric Patients with Epilepsy and Its Mechanism 　　HE Xiaoying1 FU Hua2 LIU Yonggang1 LI Xiaogang1 　　1. Department of Neurology， The Affiliated Hospital of Luzhou Medical College， Luzhou， Sichuan Province， 646000， China； 　　2 Department of Breast Surgery， The Affiliated Hospital of Luzhou Medical College， Luzhou， Sichuan Province， 646000， China 　　[Abstract] Objective To study the effect of valproic acid（VPA） on the body weight of pediatric patients with epilepsy and its mechanism. Methods 48 pediatric patients first diagnosed with epilepsy in Neurology Clinic of The Affiliated Hospital of Luzhou Medical College and treated with VPA from May， 2011 to May， 2013 were selected as the experimental group according to the inclusion criteria. The parameters of body mass index （BMI） and the serum content of leptin of them were detected before treatment and at 1， 3， 6 months after treatment. And 24 healthy children were selected as the control group. Results The BMI and the serum leptin of the experimental group both showed uptrend at 1， 3， 6 months after treatment， which were significantly higher than those of the control group at the same time point， the differences were statistically significant （P0.05）. Conclusion VPA can significantly increase the body weight of pediatric patients with epilepsy， and it may be related to the up-regulation of the serum leptin level. 　　[Key words] Valproic acid； Epilepsy； Leptin 　　随着现代医学理念的转变，在重视“病”的同时也开始重视“病人”，儿童癫痫作为一种全球性疾患，在治疗过程中既往更多关注的是药物疗效，目前药物对患者的不良反应越来越备受重视。抗癫痫药物丙戊酸钠（Valproic Acid，VPA）具有口服吸收快而完全、各种剂型生物利用度近100%