13例浅表脂肪瘤样痣临床及病分析理分析.docVIP

13例浅表脂肪瘤样痣临床及病理分析 朱和玲 林秋鸣 阮建波 张霞 王雅文 【作者单位】东莞市第五人民医院，广东 东莞 523900 【通讯作者】朱和玲，Email: 805342994@ [摘要] 目的:分析13例浅表脂肪瘤样痣患者的临床表现、组织病理和治疗，提高对本病的认识。方法: 回顾分析浅表脂肪瘤样痣患者的临床和病理组织学特点及治疗情况，并温习相关文献，对本病的临床特征进行分析。结果:浅表脂肪瘤样痣临床分多发（经典型）和单发两种类型，组织病理提示真皮中上层见无包膜且分化良好的脂肪细胞团块，与下方的皮下脂肪不相连。弹力纤维染色显示弹力纤维有不同程度的减少，破碎和断裂。结论: 浅表脂肪瘤样痣是以真皮内异位的成熟脂肪细胞为特征的一种良性错构瘤，Nevus lipomatosus cutaneous superficialis ZHU He-ling, LIN Qiu-ming, RUAN Jian-bo, ZHANG Xia, WANG Ya-wen (Department of Dermatology and Venereology, the Fifth People’s Hospital of Dongguan City, Dongguan, Guangdong Province 523900, China) [Corresponding author] ZHU He-ling, Email: 805342994@ [Abstract]: Objective: To study the clinical, histopathological and diagnostic features of nevus lipomatosus cutaneous superficialis. Methods: A retrospective case series analyse and review of literature was conducted on patients with nevus lipomatosus cutaneous superficialis. Results: Nevus lipomatosus cutaneous superficialis is classified into two clinical types: a multiple form (or classical type) and a solitary form. Histopathologically, the main feature is the presence of mature, ectopic adipocytes, embedded between collagen bundles into the dermis without connection with the hypodermis. The Verhoeff-VanGieson stain showed a marked reduction in the amount and caliber of elastic fibers in the dermis. Conclusions: Nevus lipomatosus cutaneous superficialis is an idiopathic hamartomatous disorder, characterized histopathologically by the constant presence of mature adipose tissue in the dermis. The multiple form usually is misdiagnosed to connective tissue nevus or neurofibroma, and the solitary form to tag. [Key words] Nevus lipomatosus cutaneous superficialis; Histopathology 浅表脂肪瘤样痣（nevus lipomatosus cutaneous superficialis，NLCS）是一种少见的以真皮内异位的脂肪组织聚集为特征性表现的一种错构疾病，临床容易误诊。加强对该病的临床及组织病理特点的认识，有助于提高本病的临床确诊率，指导进一步的治疗。现将我院1990～2013年间诊治的经病理学证实的13例浅表脂肪瘤样痣患者情况报告如下。 临床资料 1.1 发病年龄 13例浅表脂肪瘤样痣患者中男9例，女4例。发病年龄为17～48岁，平均25.4岁，均无家族史。 1.2 发病部位 病变位于臀部4例，肩背部2例，腹壁2例，腰部2例，胸前、