宫内早期妊娠结局同血清HCG及P水平的相关性研究.docVIP

宫内早期妊娠结局同血清HCG及P水平的相关性研究 　　[摘要] 目的 探讨血清HCG及P水平与宫内早期妊娠结局的相关性。 方法 选取2013年1月～2014年1月入住我院需要进一步进行诊治的患者240例作为研究对象。100例正常妊娠患者为A组，80例先兆流产患者为B组，60例难免流产患者为C组。取孕妇静脉血清，采用化学荧光法检测血清β-HCG和P水平。 结果 A组与C组比较，B组和C组比较，β-HCG水平有统计学差异（P20ng/mL的孕妇，宫内早期妊娠结局良好的比例显著高于其他组，差异有统计学意义（P0.01）。 结论 孕妇血清β-HCG和P水平与宫内早期妊娠结局密切相关。妊娠早期，血清β-HCG和P水平联合检测对宫内早期妊娠结局的诊断预测具有十分重要的临床意义。 　　[关键词] 早期妊娠结局；血绒毛膜促性腺激素；孕激素；相关性 　　[中图分类号] R714.1 [文献标识码] B [文章编号] 2095-0616（2015）14-87-04 　　A study on the correlation between the early intrauterine pregnancy outcome and serum HCG P levels 　　ZHOU Aihua LIU Xihong 　　Department of Gynecology， Guangming New District Center Hospital， Shenzhen 518107， China 　　[Abstract] Objective To explore the correlation between serum HCG P levels and early intrauterine pregnancy outcomes. Methods 240 hospitalized patients from January 2013 to January 2014 in our hospital who needed further diagnosis and treatment were selected as study objects. 100 patients with normal pregnancy were selected as group A， 80 patients with threatened abortion were selected as group B and 60 patients with inevitable abortion were selected as group C. Maternal venous serum was took and then chemical fluorescence was used to detect the serum β-HCG and P levels . Results Group A was compared with group C and group B was compared with group C. β-HCG level had significant differences（P20ng/mL was significantly higher than that of other groups and the difference was statistically significant（P 　　[Key words] Early intrauterine pregnancy outcome； Human serum chorionic gonadotropin； Progesterone； Correlation 　　妊娠后，应快速准确的确定妊娠结局，以指导后期的临床处理。目前，对先兆流产、难免流产等妊娠结局的诊断，主要还是依靠B超和血清学指标[1-2]。有研究表明[3-4]，B超诊断在妊娠35d后才可见到孕囊，停经一个半月后才可见原始心管搏动。所以，B超在诊断早期妊娠结局时有40%～50%的病例出现误诊[5-6]。而与妊娠密切相关的血清学指标在诊断和评价妊娠结局时发挥着非常重要的临床作用[7]。血绒毛膜促性腺激素（β-human chorionic gonadotrophin，β-HCG）和孕激素（progesterone，P）是临床上常用的妊娠相关血清学指标[8]。β-HCG在形成受精卵滋养层时开始微量分泌，受精卵着床后，母血中就能够测出β-HCG。血清β-HCG水平升高是检测妊娠的特异性指标[9-11]。孕激素在妊娠早期主要有卵巢的黄体产生，在妊娠的8～10周后，主要有胎盘产生。血清孕激素水平能够反映滋养细胞的生理功能