小儿喘息型支气管炎血清25―（OH）D3和IgE水平的检测及临床意义.docVIP

小儿喘息型支气管炎血清25―（OH）D3和IgE水平的检测及临床意义 　　[摘要] 目的 探讨小儿喘息型支气管炎血清25羟维生素D3（25-（OH）D3）和总免疫球蛋白E（lgE）的检测及临床意义。 方法 选取2012年8月～2014年8月医院收治的喘息型支气管炎患儿45例、支气管哮喘患儿45例及体检正常儿童40例作为研究对象，均行25-（OH）D3、lgE水平检测。 结果 哮喘组25-（OH）D3为（14.68±3.43）ng/mL明显低于喘支炎组（21.25±4.51）ng/mL、正常组（25.41±4.25）ng/mL，喘支炎组明显低于正常组；哮喘组lgE水平为（186.39±1.52）IU/mL明显高于喘支炎组（123.65±16.54）IU/mL、正常组（91.26±15.63）IU/mL，喘支炎组明显高于正常组，差异均具有统计学意义（P0.05）；支气管哮喘血清25-（OH）D3与lgE水平呈负相关关系（r=-7.39，P0.05）。 结论 喘息型支气管炎与支气管哮喘相似，存在血清25-（OH）D3缺乏和IgE水平升高，可将补充血清25-（OH）D3作为预防支气管哮喘的辅助疗法。 　　[关键词] 喘息型支气管炎；儿童；血清25-（OH）D3；IgE水平；临床意义 　　[中图分类号] R725.6 [文献标识码] B [文章编号] 2095-0616（2015）14-48-03 　　The detection and clinical significance of serum 25-（OH） D3 and IgE level of asthmatic bronchitis in children 　　GUO Xiaojun LU Minjun WEI Lihua 　　Department of Pediatric，Tangxia Hospital of Dongguan City，Dongguan 523710，China 　　[Abstract] Objective To investigate the detection and clinical significance of serum 25 hydroxy Vitamin D3 （25-（OH） D3） and total serum immunoglobulin E （lgE） of pediatric asthmatic bronchial asthma. Methods Selected 45 cases of bronchial asthma children，45 cases of Bronchial asthma children treated in our hospital from August 2012-August 2014，and 40 normal children as the research object，were tested with 25- （OH）D3，lgE level. Results The 25（OH） D3 asthmatic group was （14.68±3.43）ng/mL，was significantly lower than that of asthmatic bronchitis group （21.25±4.51） ng/mL，the normal group （25.41±4.25）ng/mL， asthmatic bronchitis group was significantly lower than that of normal group； asthma group lgE level was （186.39±1.52）IU/mL，was significantly higher than that of asthmatic bronchitis group （123.65±16.54） IU/mL，the normal group was （91.26±15.63） IU/mL，asthmatic bronchitis group was significantly higher than that in normal group，difference was statistically significant （P0.05）；bronchial asthma serum 25-（OH） D3 was negatively correlated with lgE level （r=-7.39，P0.05）. Conclusion Asthmatic bronchitis and bronchial asthma are similar， the prese