细胞生物学教程要点.ppt

Telomerase is a reverse transcriptase together with a template RNA It is active in germ cells, not in somatic cells, and is activated in cancers Figure 13.10 fX174 DNA can be separated into single strands by the combined effects of 3 functions: nicking with A protein, unwinding by Rep, and single-strand stabilization by SSB. 13.7 Single-stranded DNA is needed for replication Figure 13.18 DNA polymerase III holoenzyme assembles in stages, generating an enzyme complex that synthesizes the DNA of both new strands. 13.10 Coordinating synthesis of the lagging and leading strands telomerase Figur