valueofhigh-sensitivityc-reactiveproteinassaysin.ppt

Value of high-sensitivity C-reactive protein assays in predicting atrial fibrillation recurrence: a systematic review and meta-analysis by Chia-Hung Yo, Si-Huei Lee, Shy-Shin Chang, Matthew Chien-Hung Lee, and Chien-Chang Lee BMJ Open Volume 4(2):e004418 February 20, 2014 ?2014 by British Medical Journal Publishing Group A simplified flow chart to identify and to include studies. Chia-Hung Yo et al. BMJ Open 2014;4:e004418 ?2014 by British Medical Journal Publishing Group The quality assessment of diagnostic accuracy on studies. Chia-Hung Yo et al. BMJ Open 2014;4:e004418 ?2014 by British Medical Journal Publishing Group The receiver operating characteristic (ROC) curve of high-sensitivity C-reactive protein (hs-CRP). Chia-Hung Yo et al. BMJ Open 2014;4:e004418 ?2014 by British Medical Journal Publishing Group Forest plot of the ORs. Our study indicates that high-sensitivity C-reactive protein (hs-CRP) positive patients are ～5.91 times more likely to develop a recurrence of atrial fibrillation than are hs-CRP negative patients. Chia-Hung Yo et al. BMJ Open 2014;4:e004418 ?2014 by British Medical Journal Publishing Group A simplified flow chart to identify and to include studies. Among 752 citations in MEDLINE and EMBASE from inception to December 2013, a search limited to human studies using ‘C-reactive protein’ and the medical subject heading (MeSH) term ‘diagnosis of atrial fibrillation’ resulted in 32 potentially relevant articles for further review. After careful scrutinisation on full text, nine articles were left for meta-analysis. The quality assessment of diagnostic accuracy on studies. A spectrum of features were analysed to avoid bias using a well validated tool, Quality Assessment of Diagnostics Accuracy Studies (QUADAS). Percentage for each feature was independently evaluated among the studies. It is worthy of attention that none of the studies explained the withdrawal and reported undetermined results, likely to compromise the quality of diagnostic