抗胆碱酯酶药课件.pptVIP

* * 第七章 抗胆碱酯酶药 和胆碱酯酶复活药 Anticholinesterase drug and cholinesterase reactivators Cholinesterase cleans up unused acetylcholine, by breaking it down into its components acetate and choline. Neurons which produce acetylcholine are damaged in, with the result that levels of acetylcholine fall in the brain. Cholinesterase inhibitors may be useful in Alzheimers disease patients by allowing what acetylcholine there is to survive longer and be more effective. 第一节 胆碱酯酶 胆碱酯酶（cholinesterase, ChE） 乙酰胆碱酯酶（acetylcholinesterase, AChE）：主要存在胆碱能神经末梢(如运动终板)处，水解Ach 1 AchE——6×105 Ach/min 假性胆碱酯酶（ps