氯诺昔康固体分散剂的制备与表征.docxVIP

内蒙古医科大学毕业论文 题 目 氯诺昔康固体分散体的制备与表征 学生姓名 张佳玮 姚丽芳 薛猛学 号 2010092751 2010092771 2010092726 院 系 药学院专 业 药 学指导教师 刘 涛 二Ｏ一四 年 六 月 九 日 氯诺昔康固体分散体的制备和表征内蒙古医科大学2010级药学专业，呼和浩特 010059张佳玮 姚丽芳 薛猛摘要:[目的]:制备氯诺昔康不同载体固体分散体。 [方法]:选择聚乙烯吡咯烷酮K30(PVP)和泊洛沙姆这两种载体,用熔融法和溶剂法制备了氯诺昔康固 体分散体,对其进行红外光谱分析和差热图谱分析以鉴别药物在载体中的存在状态。 [结果]:熔融法和溶剂法可用于氯诺昔康固体分散体的制备,氯诺昔康可充分分散在载 体中并形成低共熔物。 [结论]:能否形成固体分散体与载体性质有关，同时载体与药物的比例也有影响，一般比例越大越 容易形成固体分散体。关键词:氯诺昔康；固体分散体；红外光谱图；差热分析。Representation and preparation of solid dispersion of lornoxicam(Department of Pharmacy, Affiliated Hospital, Inner Mongolia Medical university, Hohhot 010050 China)Abstract: [objective] : preparation of lornoxicam, different carrier solid dispersions.[methods] : select polyvinylpyrrolidone K30 (PVP) and Poloxamer this two kinds of the carrier, by using the melting method and solvent lornoxicam, solid dispersion was prepared, the infrared spectrum analysis to identify drug carrier in the state of being.[results] : melting method and solvent method can be used for lornoxicam the preparation of solid dispersions, lornoxicam, can be fully dispersed in carrier and form eutectic.. [conclusion] : can form solid dispersion related to the nature of the carrier, also has effect on the ratio of the carrier with drug at the same time, general proportion bigger is easy to form solid dispersions.Keywords: lornoxicam;Solid dispersion;Infrared spectrogram;Differential thermal analysis. 目录1 摘要.......................................................................................12 前言.......................................................................................53 仪器与材料.............................................................................64 实验方法64.1氯诺昔康的提取64.1.1提取64.1.2重结晶：7 4.1.3滤渣提取..........................................................................74.2氯诺昔康固体分散体的制备7 4.2.1固体分散体Ⅰ.....................................................7 4.2.2固体分散体Ⅱ7 4.3氯诺昔康固体分散体的表征......................................75 结果与讨论...............