Green Chemistry Case Studies Presidential Green 绿色化学案例研究总统绿色.pptVIP

Nicole Casasnovas Hannah Needleman July 2012 * Case 2: Codexis, Inc. Dr. Yi Tang, UCLA Winner in the Area of Greener Synthetic Pathways * Overview Title: An Efficient Biocatalytic Process to Manufacture Simvastatin Summary: Simvastatin, a leading drug for treating high cholesterol, is manufactured from a natural product. The traditional multistep synthesis was wasteful and used large amounts of hazardous reagents. Professor Tang conceived a synthesis using an engineered enzyme and a practical low-cost feedstock. Codexis optimized both the enzyme and the chemical process. The resulting pro