PathogenDerived Immunomodulatory Molecules Future来自病原体的免疫调节分子的未来.pptVIP

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2017-03-08 发布于上海
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PathogenDerived Immunomodulatory Molecules Future来自病原体的免疫调节分子的未来.ppt

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PathogenDerived Immunomodulatory Molecules Future来自病原体的免疫调节分子的未来

Pathogen-Derived Immunomodulatory Molecules: Future Therapeutics? Padraic G. Fallon and Antonio Alcami (2006) Rafael Sanchez ABSTRACT Rapid developing area of research: Identifying molecules from various pathogens that modulate the innate or adaptive immune systems. Immunomodulatory molecules: Have been optimized during pathogen/host co-evolution and could be used as new immunotherapeutics. Immunomodulatory molecules (IM) selectively mimic the desirable effects of infection. Main Focus: Demonstrate the use of these pathogen IM’s that have been produced as recombinant proteins of which have different modes of modulatory activity, and discuss their ability to change undesirable immune responses caused by human diseases. Important Idea: Understanding the mechanisms that pathogens have evolved to manipulate host immunity might help to result in new therapeutics for inflammatory diseases. Methods: Address all Examples of pathogen IM’s that come from viruses, bacteria, and parasites. Serp-1 Comes from the Myoxa virus, poxvirus in rabbits. encodes a secreted serine-protease inhibitor (serpin)?Serp-1. Could be the first pathogen IM available for patients. Serp-1 blocks atherosclerotic-plaque growth in models of arterial trauma, Has beneficial effects in aortic and heart-transplant models, and also in a model of antigen-induced arthritis Studies have established that viral IM can be effective at low doses, and have the ability to reduce the degree of the initial pro-inflammatory stimuli and the ensuing chronic inflammatory response that causes immunopathology after physical trauma. Currently in phase 2 of clinical testing on patients with acute coronary syndrome. Other IM inhibitors Secreted vaccinia complement-control protein (VCP): Has anti-inflammatory property. Prolongs survival after heart transplants VCP also shows an effect in animal models of injury to the central nervous system Orthologue encoded by cowpox virus, known as inflammatory modulatory protein