盐酸羟考酮缓释片不同给药途径治疗癌痛的疗效及安全性观察.docVIP

盐酸羟考酮缓释片不同给药途径治疗癌痛的疗效及安全性观察 　　摘要：目的 观察盐酸羟考酮缓释片口服与直肠给药两种途径治疗癌痛的疗效和不良反应。方法 选择锦州医科大学附属一院肿瘤科2010年9月～2015年9月128例癌痛患者，随机数字表法将128例患者分为口服给药组和直肠给药组每组64例，比较两种给药途径的缓解疼痛的疗效以及不良反应发生情况。结果 口服给药组疼痛缓解有效率为92.18%，直肠给药组有效率为93.75%，两组的疗效无统计学意义（P0.05）。口服给药不良反应65.62%，直肠给药不良反应39.06%，两组的疗效无统计学意义（P0.05）。结论 直肠给药与口服给药止痛效果相当，直肠给药不良反应少，对于口服困难的患者不失为一种方便安全有效的方法。 　　关键词：盐酸羟考酮缓释片；癌痛 　　Oxycodone Hydrochloride Sustained-release Tablets to Observe the Safety and Efficacy of Drug 　　Treatment of Cancer Pain 　　HAN Qiu-yue 　　（Oncology Department，The First Affiliated Hospital of Jinzhou Medical University，Jinzhou 121001，Liaoning，China） 　　Abstract：Objective Observation of oxycodone hydrochloride oral and rectal administration and adverse reactions in two ways in the treatment of cancer pain treatment.Methods In Jin Zhou Medical University First Affiliated Hospital oncology September 2010 to 2015 September 128 cases of patients with cancer pain， the random number table method 128 cases of patients was given to treatment group and rectum give medicine group （n = 64 cases）. The comparison of the two to medicine way alleviate the curative effect and adverse reaction of pain conditions.Results The effective rate of pain relief in oral administration group was 92.18%， the effective rate was 93.75%， and the curative effect was not statistically significant （P0.05） in two groups. The adverse drug reaction of oral administration was 65.62%， the adverse effect of rectal administration was 39.06%， and the curative effect of the two groups was not statistically significant （P0.05）.Conclusion Rectal administration and oral administration to relieve pain effect is equivalent， rectal administration adverse reaction less， for patients with oral difficulty is a convenient and safe and effective way. 　　Key words：Oxycodone Hydrochloride Prolonged-release Tablets；Cancer pain 　　癌性疼痛（癌痛）是癌症患者常见的症状，特别是中晚期患者。癌痛不仅严重威胁患者的生存质量，也会对家庭造成沉重的负担。特别是对于那些不能口服给药的癌痛患者，寻找一种便捷、有效的止痛方法十分重要。盐酸羟考酮缓释片，中度以上癌性疼痛的常用阿片类药物，通过中枢μ受体和κ受体发挥镇痛作用[1]。