谷氨酰胺代谢与肿瘤.pdfVIP

第25卷第11期 生命科学 Vol. 25, No. 11 2013年11月 Chinese Bulletin of Life Sciences Nov., 2013 文章编号：1004-0374(2013) 11-1109-06 谷氨酰胺代谢与肿瘤 张文静1* 2 ，卿国良 (1 湖北文理学院医学院，襄阳44 1053 ；2 华中科技大学同济医学院，武汉430030) 摘　要：“谷氨酰胺代谢”是肿瘤细胞除Warburg 效应外又一重要的能量代谢方式。迅速增殖的肿瘤细胞消 耗谷氨酰胺(glutamine, Gln) 来提供生长和增殖所需的能量和生物大分子原料, 维持细胞内氧化还原稳态和 Gln 参与细胞内信号通路的转导。肿瘤中原癌基因与抑癌基因的突变会影响 代谢。结合先进的诊断技术和 Gln Gln Gln 研究手段将有利于了解肿瘤中 的生化代谢，揭示 代谢的关键环节，为依赖 的肿瘤提供治疗新 策略。 关键词：谷氨酰胺 ；代谢 ；肿瘤 ；代谢显像 Q517 R730.53 A 中图分类号： ； 文献标志码 ： Glutamine metabolism and cancer ZHANG Wen-Jing1*, QING Guo-Liang2 (1 Medical College, Hubei University of Arts and Science, Xiangyang 441053, China; 2 Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China) Abstract: Glutamine metabolism is recognized as a distinctive feature in addition to Warburg effect in cancer. Cancer cells acquire energy and nutrients through glutamine metabolism to support cell growth and proliferation. Moreover, glutamine metabolism maintains redox homeostasis and modulates cellular signal transduction. Several oncogenes and anti-oncogenes in cancers have been reported to influence glutamine metabolism. Modern diagnostic techniques combined with new methods will facilitate understanding of the biochemical processes of glutamine metabolism, unveiling the novel target and providing new therapeutics for glutamine-addicted cancers. Key words: glutamine; metabol