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Microfluidic fabrication of chitosan microfibers with controllable internals from tubular to peapod.pdf

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Microfluidic fabrication of chitosan microfibers with controllable internals from tubular to peapod

RSC Advances PAPER P u b l i s h e d o n 1 9 N o v e m b e r 2 0 1 4 . D o w n l o a d e d b y U n i v e r s i t y o f P e n n s y l v a n i a L i b r a r i e s o n 1 5 / 0 1 / 2 0 1 5 1 8 : 2 7 : 1 2 . View Article Online View Journal | View IssueMicrofluidic fabraSchool of Chemical Engineering, Sichuan China. E-mail: wangwei512@; ch Tel: +86-28-8546-0682 bState Key Laboratory of Polymer Materials E Center for Biomaterials Science and Tec Sichuan, 610065, China ? Electronic supplementary information microuidic fabrication and morpholog microbers, and Fig. S4 and Table S1 chitosan microbers. See DOI: 10.1039/c4 Cite this: RSC Adv., 2015, 5, 928 Received 18th September 2014 Accepted 18th November 2014 DOI: 10.1039/c4ra10696b /advances 928 | RSC Adv., 2015, 5, 928–936ication of chitosan microfibers with controllable internals from tubular to peapod- like structures? Xiao-Heng He,a Wei Wang,*a Ke Deng,a Rui Xie,a Xiao-Jie Ju,a Zhuang Liua and Liang-Yin Chu*ab Here we report on a simple and flexible approach for continuous in situ fabrication of chitosan microfibers with controllable internals from tubular to peapod-like structures in microfluidics. Tubular and peapod-like jet templates can be generated at stable operation regions for template synthesis of chitosan microfibers with controllable tubular and peapod-like internals. The structure of each jet template can be precisely adjusted by simply changing the flow rates to tailor the structures of the resultant tubular and peapod- like chitosan microfibers. Both the tubular and peapod-like microfibers possess sufficient mechanical properties for further handling for biomedical applications. The tubular microfibers are used as biocompatible artificial vessels for transporting fluid, which is promising for delivering nutrition and blood for tissue engineering and cell culture. The peapod-like microfibers with controllable and separate oil cores can serve as multi-compartment systems for synergistic enc