Malignant glomus tumor of the lung.pdfVIP

Pathology International 2003; 53: 632–636 Blackwell Science, LtdOxford, UKPINPathology International1320Japanese Society of PathologySeptember 2003539632636Case ReportMalignant glomus tumor of the lungT. Hishida et al . Correspondence: Tadashi Hasegawa, MD, Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Email: tdhasega@ncc.go.jp Received 29 November 2002. Accepted for publication 26 April 2003. Case Report Malignant glomus tumor of the lung Tomoyuki Hishida,1,4 Tadashi Hasegawa,2 Hisao Asamura,1 Masahiko Kusumoto,3 Arafumi Maeshima,2 Yoshihiro Matsuno,4 Kenji Suzuki,1 Haruhiko Kondo1 and Ryosuke Tsuchiya1 1Thoracic Surgery Division, National Cancer Center Hospital, 2Pathology Division, National Cancer Center Research Institute, 3Diagnostic Radiology and 4Clinical Laboratory Divisions, National Cancer Center Hospital, Tokyo, Japan Primary malignant glomus tumors of the lung are extremely rare, and to our knowledge, only three cases have been described to date. We report one such case in a 53-year-old man who presented with a persistent dry cough. Chest computed tomography scans demonstrated an irregularly shaped mass in the right lower lobe of the lung. Many small nodules were distributed from the main tumor to the periph- ery, along with bronchovascular bundles. Right lower lobec- tomy was performed under the diagnosis of lung tumor. The tumor was located in the proximal portion of the right lower lobe and extended along the pulmonary arteries. Histologi- cal examination revealed a sheet-like proliferation of epithe- lioid glomus cells and fascicles of spindle cells. The pres- ence of increased mitotic activity, tumor necrosis and prominent intravascular invasion suggested malignancy. The tumor cells were immunoreactive for vimentin, calpo- nin, h-caldesmon, and α-smooth muscle actin, which indi- cated definitive smooth muscle differentiation. We believe that this is the fourth reported cas