持续不卧床腹膜透析腹膜腹透液中氨基酸的丢失.pdfVIP

透析与人工器官 2011 年 9 月(第 22 卷)第 3 期 持续不卧床腹膜透析腹膜腹透液中氨基酸的丢失 范亚平，蒋季杰，钱桐蒜，詹久生，李炳源 [摘要] 4 例短期 CAPD( 平均 2.6 月)患者采用拉丁方设计测定了腹透液中氨基酸丢失量及 血浆游离氨基酸谱，结果常规 CAPD 每日氨基酸丢失总量约 2 g( (194.47+22.12 )mgIL)，其中 1 /3 为必需氨基酸，腹透液中氨基酸丢失量与常用腹透液种类无明显关系，个体差异不大，而与腹透 液腹腔内保留时间相关。短期 CAPD 对尿毒症血浆游离氨基酸谱异常及总必需氨基酸/总非必需 氨基酸、酷氨酸/苯丙氨酸、丝氨酸/甘氨酸、缴氨酸/甘氨酸等 4 项比值降低元明显改善。 [关键词] 持续不卧床腹膜透析;慢性肾功能衰竭;腹透液;氨基酸 中图分类号: R 692.5 文献标志码 :A 文章编号 :1005-0809(2011)03-∞01 一04 Amino Acid Losses in Dialysate During Continuous Ambulatory Peritoneal Dialysis FAN Ya-ping, JIANG Ji-jie, QIAN Tong-sun, ZHAN Jiu-sheng, LI Bing-yuan (Division 0/ Nephrology, the Affilia1ed Hospita1 0/ NOIltong Medic a1 University, Jiαngsu NOIltong 226001, China) [Abstract] The losses in dialysate and the plasma free concentrations of 16 amino aids were measured in four short-term CAPD patients (mean 2.6 months )by HPLC method, which showed that the amino acid losses during regular CAPD were about 2 g/d (194.47 :t 22.12 mgIL dialysate) 9 in which the essential amino acids accounted for V3 or so Using a latin square design, we found that the amino acid losses indislysate were increased with the duration of interperitoneal residance, but bore litùe relation to the kinds of dialysates and different patients. Short-term CAPD did not correct the plasma abnormal amino acid levels in uremic patients and made litùe improvement on the decreased four items (to凶 essential amino acids/totalnon-essential amino acids, tyrosine/phenylanine, serine/glysine and valine/glysine).