After an mixture of anti-oxytocin-induced dysmenorrhea experimental study.docVIP

 PAGE \* MERGEFORMAT 4 After an mixture of anti-oxytocin-induced dysmenorrhea experimental study [Abstract] Objective: To evaluate the mixture an antagonist of oxytocin-induced experimental effect and mechanism of dysmenorrhea. Methods: Oxytocin-induced dysmenorrhea model of rat writhing pain response times and to radioimmunoassay of rat uterus PGF2α (prostaglandin F2α ), PGE2 (prostaglandin E2) levels and plasma β -EP (β -endorphin) content. Results: An mixture significantly inhibited oxytocin-induced writhing in rats the number of regulating uterine PGF2α , PGE2 levels, increase plasma β -EP content. Conclusion: The mixture can be antagonized by an oxytocin-induced experimental dysmenorrhea, the role of its anti-dysmenorrhea may be related to the dose adjustment of uterine PGF2α and PGF2 content, an increase of plasma β -EP related to the content. [Keywords:] An agent; dysmenorrhea model; prostaglandin F2α ; prostaglandin E2; β -endorphin The mixture is an Bupleurum, Chinese angelica, Chuanxiong, turmeric, Corydalis and other preparations consisting of eight Chinese herbal medicines for the treatment of primary dysmenorrhea. In this study, to be adopted by the Security mixture on oxytocin-induced experimental pharmacological effects of dysmenorrhea, preliminary study of the analgesic effect of preparations for treatment of dysmenorrhea and its mechanism. An experimental material 1.1 Drugs After an mixture, the concentration of 200%, Affiliated Hospital of Hubei Traditional Chinese Medicine preparation room provided. Oxytocin injection, the Shanghai No. 1 Biochemical Pharmaceutical Co., Ltd.. Diethylstilbestrol injection, Shanghai GM Pharmaceutical Co., Ltd.. Aspirin tablets: Shanghai 9th pharmaceutical products. β -EP radioimmunoassay kit, Beijing Hartcourt sharp Biotechnology Center. PGF2α , PGE2 RIA kit, Beijing, Chinese Academy of Medical Sciences Peking Union Medical College isotope Room of large basis. 1.2 Animals Wistar rats weighing 2