Chronic myeloid leukemia increased significantly starting platelet.docVIP

 PAGE \* MERGEFORMAT 20 Chronic myeloid leukemia increased significantly starting platelet Author: Shen Qun, Zhou Jian-Wei, Guang-Rong Zhu, Yang Yan, Hai-Rong Qiu, Zhu Guangrong, Xia Wen, Peng Jiang Jun Abstract of this study was to explore the significant increase in platelet-starter of chronic myeloid leukemia (CML) the clinical, cytogenetic and molecular biological characteristics. Application of bone marrow smears, bone marrow biopsy morphologic changes of cells were observed; RT-PCR detection of bcr / abl fusion gene; conventional karyotype analysis and FISH detection of cytogenetic changes. The results showed that: The significant increase in platelets as the first performance of a group of CML is a unique clinical and biological characteristics of the disease, bone marrow smears and bone marrow biopsy showed active bone marrow hyperplasia, to megakaryocyte dysplasia mainly large piles of platelets , we can see a small round of nuclear megakaryocyte medium degree of leukocytosis by cell genetics and molecular biology have confirmed the existence of Ph chromosome and (or) expression of bcr / abl fusion gene, such patients should be active early treatment, or even the intervention of the level of molecular biology; and essential thrombocythemia (ET) in patients with the use of chemotherapy drugs should not be too much, otherwise the contrary, the incidence of induced leukemia. Conclusion: The significant increase in platelets in patients with Ph chromosome should be promptly and bcr / abl fusion gene expression level of detection, which for the ET and the diagnosis and differential diagnosis of CML is extremely important in order to avoid misdiagnosis, wrong administration. Keywords: Essential thrombocythemia Chronic Myeloid Leukemia Onset with Marked Thrombocythemia Abstract This study was aimed to investigate the clinical, pathological and biological features of a special case of chronic myeloid leukemia (CML) with marked