Chronic obstructive pulmonary disease patients the level of serum paraoxonase relationship with systemic inflammatory response.docVIP

Chronic obstructive pulmonary disease patients the level of serum paraoxonase relationship with systemic inflammatory response.doc

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 PAGE \* MERGEFORMAT 14 Chronic obstructive pulmonary disease patients the level of serum paraoxonase relationship with systemic inflammatory response Of: sailing Liuxiao Ju Zhang Yi Zhang Hairong package [Abstract] Objective To investigate the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients with serum paraoxonase (PON1), oxidative stress and the relationship between systemic inflammation. Methods phenyl acetate were detected 40 cases of AECOPD patients and 30 normal control of serum PON1 activity; improved Hafeman determine serum glutathione peroxidase (GSH Px) activity; colorimetric determination of total antioxidant capacity (TAC); thiobarbituric acid determination of malondialdehyde color (MDA); RIA serum levels of IL 6 and IL 8; immune serum turbidimetry projection C-reactive protein (CRP) levels. Results of serum PON1 activity in AECOPD (95.03 + -57.4) U / ml was significantly lower than control group (136.0 + -60.5) U / ml, GSH Px activity (128.46 + -28.27) U / ml than the control group (186.60 + -39.50) U / ml (P lt;0.05), serum MDA (6.25 + -0.87) nmol / ml was significantly higher (3.65 + -0.54) nmol / ml (P lt;0.01), serum TAC (9.86 + -3.19) nU / ml was significantly lower than the control group (18.42 + -8.23) nU / ml (P lt;0.01); IL 6 (64.86 + -20.27) pg / ml, CRP (9.23 + -4.58) mg / L was significantly higher (46.32 + -12.25) pg / ml, (3.34 + -1.29) mg / L (all P lt;0.01); IL 8 (2.63 + -0.75) ng / ml higher (1.82 + -0.67) ng / ml (P lt;0.05); PON1 activity and IL 8 were significantly negatively correlated (r =- 0.589, P lt;0.01), and FEV1% was positively correlated (r = 0.434, P lt;0.05), GSH Px activity and IL 6 was negatively correlated (r =- 0.362, P lt;0.05), MDA and CRP were positively correlated ( r = 0.512, P lt;0.01), and FEV1% were significantly negative correlation (r =- 0.800, P lt;0.01), TAC and IL 6 was significantly negatively correlated (r =- 0.573, P lt;0.01), and FEV1% was positively correlati

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