Chymotrypsin and dexamethasone in children with acute lymphoblastic leukemia NF κB expression and its significance.docVIP
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Chymotrypsin and dexamethasone in children with acute lymphoblastic leukemia NF κB expression and its significance
Author: Yang Xu Wei Gao Qi Xue days Yoshiteru WU YI Xu Chunping
Abstract This study investigated the chymotrypsin (N tosyl L phenylalnylchloromethyl ketone, TPCK) and dexamethasone (dexamethasone, Dex) for children with acute lymphoblastic leukemia (ALL) of nuclear transcription factor κB (NF κB) expression and significance of clinical seeking NF κB as a target means to provide the scientific basis of treatment. Application of SP immunohistochemical method detected 20 cases of ALL in children with NF κB P65 protein expression and detection of TPCK and Dex on ALL cells, NF κB P65 protein activity. The results showed that: 40 μmol / L of TPCK can be very significant to inhibit ALL cell NF κB P65 protein activation, the role of 2 hours, ALL cells, NF κB P65 protein expression to negative, positive expression rate (2.5 ± 1.6 )%; and TPCK on NF κB P65 protein, inhibition of activity within a certain range with a time-dependent. Clinical treatment-related dose of Dex 5.0 μg / ml act on ALL cells, 24 hours, can very significantly inhibited NF κB P65 protein expression, the positive expression rate (25.0 ± 3.0)%; compared with the baseline state, there is a significant difference (T = 55, P lt;0.01). Conclusion: TPCK, and Dex inhibit NF κB activity, NF κB inhibitory activity of Dex may be acting on the children ALL cells, one of the mechanisms. Inhibit NF κB signal transduction pathway may be the treatment of ALL in children has great value.
Keywords: Acute lymphoblastic leukemia; nuclear transcription factor κB; Chymotrypsin; dexamethasone
Effect of N tosyl L phenylalnylchloromethyl Ketone and Dexa methasone on Expression of Nuclear Transcription Factor κB in Childhood Acute Lymphoblastic Leukemia and Its Significance
Abstract In order to investigate the eff
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