Chymotrypsin and dexamethasone in children with acute lymphoblastic leukemia NF κB expression and its significance.docVIP

Chymotrypsin and dexamethasone in children with acute lymphoblastic leukemia NF κB expression and its significance.doc

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 PAGE \* MERGEFORMAT 25 Chymotrypsin and dexamethasone in children with acute lymphoblastic leukemia NF κB expression and its significance Author: Yang Xu Wei Gao Qi Xue days Yoshiteru WU YI Xu Chunping Abstract This study investigated the chymotrypsin (N  tosyl  L  phenylalnylchloromethyl ketone, TPCK) and dexamethasone (dexamethasone, Dex) for children with acute lymphoblastic leukemia (ALL) of nuclear transcription factor  κB (NF  κB) expression and significance of clinical seeking NF  κB as a target means to provide the scientific basis of treatment. Application of SP immunohistochemical method detected 20 cases of ALL in children with NF  κB P65 protein expression and detection of TPCK and Dex on ALL cells, NF  κB P65 protein activity. The results showed that: 40 μmol / L of TPCK can be very significant to inhibit ALL cell NF  κB P65 protein activation, the role of 2 hours, ALL cells, NF  κB P65 protein expression to negative, positive expression rate (2.5 ± 1.6 )%; and TPCK on NF  κB P65 protein, inhibition of activity within a certain range with a time-dependent. Clinical treatment-related dose of Dex 5.0 μg / ml act on ALL cells, 24 hours, can very significantly inhibited NF  κB P65 protein expression, the positive expression rate (25.0 ± 3.0)%; compared with the baseline state, there is a significant difference (T = 55, P lt;0.01). Conclusion: TPCK, and Dex inhibit NF  κB activity, NF  κB inhibitory activity of Dex may be acting on the children ALL cells, one of the mechanisms. Inhibit NF  κB signal transduction pathway may be the treatment of ALL in children has great value. Keywords: Acute lymphoblastic leukemia; nuclear transcription factor  κB; Chymotrypsin; dexamethasone Effect of N  tosyl  L  phenylalnylchloromethyl Ketone and Dexa  methasone on Expression of Nuclear Transcription Factor  κB in Childhood Acute Lymphoblastic Leukemia and Its Significance Abstract In order to investigate the eff

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