Ciliary neurotrophic factor and its receptor in Progress.docVIP

 PAGE \* MERGEFORMAT 11 Ciliary neurotrophic factor and its receptor in Progress Keywords:: ciliary neurotrophic factor receptor gene expression in Summary of ciliary neurotrophic factor (CNTF) has been found since the 70’s increased attention devoted to their nerve cell growth, differentiation has obvious nutritional role. CNTF and its receptor in the tissue distribution, molecular structure of proteins and genes, growth, learning activity, expression and regulation, etc. has made new progress in research and demonstrated the clinical application. Cohen was purified in 1956, the first neurotrophic factor - nerve growth factor (NGF), then gradually found a brain-derived neurotrophic factor (BDNF), neurotrophin -3 (NT-3), neurotrophic factor -4 / 5 (NT-4 / 5), constitute a neurotrophic factor (NT-Fs) family, their nerve cell growth, differentiation plays an important role. Ciliary neurotrophic factor (ciliary neurotrophic factor, CNTF) from the birds because of the initial extracted ciliary ganglion, parasympathetic ganglia activity can be maintained so named, it does not belong to NTFs family members, rather than non-homology, is a non - target-derived neurotrophic factor. CNTF was first proposed by Helfand and so in 1976 found that in 1984, Barbin, etc. extracted from the chicken ciliary neurons to obtain, and in 1989 received CNTF cDNA. 1 CNTF and its receptor in tissue distribution ⑴ CNTF-positive cells in the central nervous system, CNTF-positive cells were mainly distributed in the cerebral cortex, olfactory bulb, cerebellum, subcortical area. Type Ⅰ in vitro CNTF expression in glial cells can also be found. Intracellular Positioning: glial cells mainly in the cell body with prominent negative, neurons in the nucleus, cytoplasm was negative [1]; but there are inconsistencies in the reports [2]. In the peripheral nervous system, CNTF mainly distributed in the myelin / Schwann cells, ciliary ganglion; Schwann cells showed a high level of expression of