Elimination of deep brain stimulation in rats Experimental Study of artifacts.docVIP

 PAGE \* MERGEFORMAT 9 Elimination of deep brain stimulation in rats Experimental Study of artifacts Study: High-Dong Ming Liu Chunna, Kang Ning, Lin Yuhan, Zhang Xiaoli [Abstract] Objective To eliminate stimulus artifact to reveal the mechanism of DBS. Methods Spike 2 system-specific biological signal processing, integrated use of digital filtering, dual window method of identifying potential and the signal waveform to eliminate stimulus artifact. Results stimulus artifact treatment can clear brain to eliminate high-frequency stimulation of neuronal discharge during the change. Conclusion Our method can effectively remove the stimulus artifact. [Keywords:] Deep brain stimulation; stimulus artifact; rat Abstract: Objective The research aims to remove the stimulus artifact, and to explore the mechanism of deep brain stimulation. Methods Through using the functions of digital filter, spike waveform detection and potential filter in two windows performed by the Spike 2 system, the stimulus artifact was eliminated.Results The change of neural discharge activities during deep brain stimulation could be revealed clearly.Conclusions The method can be effectively used in the stimulus artifact removal. Keywords:: deep brain stimulation; stimulus artifact; rat Since 1987 the famous French professor of neurosurgery experts successfully applied Benabid ventromedial hypothalamic nucleus (VIM) high-frequency stimulation for Parkinson disease (PD) since the target for the VIM, medial globus pallidus (PGI) or the subthalamic nucleus (STN) deep brain stimulation (deep brain stimulation, DBS) has become an international functional neurosurgery preferred method of treatment of PD [1,2]. People also try to use the DBS treatment of central pain [3], epilepsy [4,5] and other diseases, even for drug treatment and obesity [6] treatment. but because of the powerful stimulus artifact obscures the stimulation on electrical activity of neurons, it is the role and the lat