Elimination of nuclear piece of drug-induced liver injury in clinical analysis of 12 cases.docVIP

 PAGE \* MERGEFORMAT 5 Elimination of nuclear piece of drug-induced liver injury in clinical analysis of 12 cases [Keywords:] elimination of nuclear tablets drug-induced liver injury Elimination of nuclear film is the treatment of female breast hyperplasia of Chinese traditional medicines, although the drug in clinical use of time is longer, but it has led to drug-induced liver injury cases are mostly reported. Therefore, we have our hospital from 2004 to 2007 were treated 12 cases of extinction by taking cases of liver injury caused by the nuclear piece, do the following clinical analysis. A clinical data 1.1 Generally 12 cases were female, age (25 ~ 49) years, with an average 35.33 years of age. All patients were taking the risk of mammary hyperplasia and the elimination of nuclear tablets, 2 tablets / time, 3 times / day. Medication with the onset time for amp;quot;15 days in 2 cases (16.6%); January ~ 3 months in 1 case (8.3%); April ~ June 3 cases (25.0%); from 6 months to 1 year (5 cases, accounted for 41.6%); amp;quot;1 1 cases (8.3%). All cases, neither medication was added during the Liver drug. 12 cases of hepatitis virus markers were negative, and the exclusion of other causes of liver damage. 1.2 clinical symptoms and signs appear in 12 cases of fatigue in 8 cases (66.6%), anorexia in 6 cases (50.0%), tired greasy food in 5 cases (41.6%), nausea and vomiting in 4 cases (33.3%), four cases of upper abdominal discomfort (33.3%), skin itching in 3 cases (25.0%), stool color lighter in 2 cases (16.6%). Palpation of the skin and sclera yellow dye found in eight cases, four cases of upper abdominal tenderness, hepatomegaly in 3 cases, liver knocking pain in 4 cases. 1.3 auxiliary examination of liver function test, ALT (981 ~ 187) U / L, an average of 500.97U / L, AST (674 ~ 128.7) U / L, an average of 389.53U / L, GGT (115.4 ~ 26.4) U / L, an average of 83.3U / L, TBil (275.5 ~ 8.0) μ mol / L, an average of 96.58 μ mol / L, ALP (64.1 ~ 160) U / L,