Elk horn alcohol extract of the antioxidant effect of aging mice.docVIP

 PAGE \* MERGEFORMAT 11 Elk horn alcohol extract of the antioxidant effect of aging mice Of: Qin Hongbing ZHU Qing YANG Chao Yexiongcunquan [Abstract] Objective To observe the elk horn alcohol extract of D-galactose (D-gal induced aging mice antioxidant activity. Methods 54 ICR mice of either sex were randomly divided into 4 groups: normal control group (NG , n = 12, model group (MG, n = 14, elk horn alcohol extract low dose group (LG, 2 g kg-1 d-1, n = 14, elk horn alcohol extract high-dose group ( HG, 4 g kg-1 d-1, n = 14. the normal control group were given subcutaneous injection of saline, the rest of the group with D-galactose (D-gal at 120 mg kg-1 d-1 subcutaneous injection for 6 weeks, resulting in subacute aging model. modeling the same time, elk horn alcohol extract low dose group and high dose group were given the appropriate concentration of alcohol extract of deer horn, the normal control group and model control group were given the same volume 0.5% sodium carboxymethyl cellulose (CMC. and determination of serum superoxide dismutase (SOD activity and malondialdehyde (MDA content, and determination of brain lipofuscin (LP and liver glutathione levels have peroxidase (GSH-Px activity. Results The serum levels of liver SOD and GSH-Px activity decreased, serum MDA and LP levels in the brain were increased, while the alcohol extract of deer horn can improve the aging mice serum SOD, serum MDA, and to reduce the content of the brain LP. Conclusion alcohol extract of deer horn on the D-gal induced aging mice with anti-oxidation. [Keywords:] elk horn Aging Antioxidant D-galactose Abstract: ObjectiveTo investigate the antioxidation of Elk antlers ethanolic extract on aging model mice induced by D-galactose. Methods54 ICR mice were randomly divided into 4 groups: normal control group (NG, n = 12), model control group (MG, n = 14), low-dose drug treatment group (LG, 2 g kg-1 d-1, n = 14), high-dose drug treatment group (HG, 4 g kg-1 d-1,