Emodin and astragalus polysaccharides on experimental liver injury in rat liver ultrastructure.docVIP

 PAGE \* MERGEFORMAT 15 Emodin and astragalus polysaccharides on experimental liver injury in rat liver ultrastructure Of: Zhang Xin, the party double locks, Cheng Yanan, Gu Xiaoli, Chen Mingxia, Liu Enqi [Abstract] Objective emodin and Astragalus polysaccharides alone and in combination on liver injury in rats and significance of liver ultrastructure. Methods carbon tetrachloride (CCl4) induced by multiple factors such as liver injury model. Select the Clean 90 male SD rats were randomly divided into 6 groups: normal control group (10), model group (20), emodin group (15), APS group (15), emodin and Astragalus polysaccharide group (15), colchicine group (15). In addition to the normal control group and simply made the same time other groups outside the module to the corresponding drug intervention, that emodin 40mg / (kg d), APS 200mg / (kg d), emodin 40mg / (kg d) + APS 200mg / (kg d), colchicine 0.1mg / (kg d), a total of 12 weeks. collected liver tissue samples were measured after hydroxyproline (Hyp) content, electron microscopy of the ultrastructure of rat liver. Results Emodin, APS, both alone or in combination, can reduce CCl4 on liver tissue damage, especially in combination therapy can be Hyp content in liver tissue was significantly reduced; protect the liver ultrastructural changes, showed near-normal liver cell structure, envelope warping, see a small amount of lipid droplets within the cytoplasm, regular arrangement of mitochondria and endoplasmic reticulum proliferation, and dilated sinusoids gap shows fusiform or rod-shaped hepatic stellate cells (HSC), the glut of small sinusoidal thin collagen fiber bundles, Kupffer cells small lipid droplets. CONCLUSION emodin and astragalus polysaccharides on the ultrastructure of CCl4 liver injury in rats have some preventive effect. [Keywords:] emodin; APS; liver injury; ultrastructure; rat ABSTRACT: Objective To explore the effect and significance of emodin and astragalus polysaccharides