Levamlodipine treat high blood pressure angina pectoris.docVIP

 PAGE \* MERGEFORMAT 6 Levamlodipine treat high blood pressure angina pectoris [Keywords:] levamlodipine dihydropyridine calcium channel blockers high blood pressure Angina Levamlodipine (l  amlodipine, trade name: SHI Hui-up) (s)  ( )  3  ethyl-5  methyl  2  (2  ammonia ethoxymethyl)  4  (2  chloro - phenyl)  1,4  dihydro  6  methyl  3,5  pyridine-2-carboxylic acid ester, a molecular weight of 567.05. Is a new generation long-acting dihydropyridine calcium channel blockers (calcium.channei.biock.CCB), is the amlodipine besylate (amlodipine) for replacements. Amlodipine is a racemic mixture, L-amlodipine is through chiral separation technology acquired levamlodipine of the pharmacologically active parts of the same dose of L-amlodipine their pharmacological activity of racemic 2 times is a D-body 1000 times. As removed almost no pharmacological activity and toxicity of the right-hand part of the larger, so levamlodipine to retain all the pharmacological activity of amlodipine on the basis of the clinical use to improve the safety of [1]. A clinical application The main clinical for the treatment of high blood pressure, angina pectoris. The role of blood pressure is characterized by persistent, stable, high security and resistance to insulin, blood sugar, blood lipids had no effect, adverse reaction rates lower than amlodipine. The main adverse reactions were headache, edema, fatigue, insomnia, nausea, abdominal pain, face red, heart palpitations and dizziness; itching, rash, difficulty breathing, weakness, muscle cramps and indigestion uncommon; very few adverse myocardial infarction and chest pain response to reports, these adverse reactions and the patient’s underlying disease a clear distinction. 2 Pharmacological Research Levamlodipine for calcium blockers, through the calcium flow, reducing myocardial contractility, cardiac and vascular smooth muscle cells, blocking calcium ions through the cell membrane calcium