pH-sensitive chitosan - sodium alginate hydrogels Preparation and Properties of.doc

 PAGE \* MERGEFORMAT 12 pH-sensitive chitosan / sodium alginate hydrogels Preparation and Properties of [Abstract] Objective To prepare the chitosan / alginate hydrogel nifedipine, examining different concentrations and ratios of chitosan and sodium alginate controlled release of drugs and to examine the pH-sensitive hydrogel. Methods Complex Coacervation nifedipine hydrogel, by changing the concentration of excipients to examine the role of its slow-release nifedipine using orthogonal design the best process; use to blue water gel Law Institute release rate, by changing the release medium pH, to study the slow-release drugs on the pH sensitivity. Results chitosan concentration of 0.4%, 1.5% sodium alginate concentration, stirring speed 160r/min, chitosan solution and sodium alginate solution when the volume ratio of 6:1 as the best process. Nifedipine gel in artificial gastric juice with little or no dissolved in artificial intestinal fluid 4h completely dissolved. Conclusions Nifedipine hydrogel has obvious sustained release effect and strong pH sensitivity. [Keywords:] pH sensitivity; nifedipine; chitosan; sodium alginate; Release [Abstract] Objective To prepare chitosan-sodium alginate hydrogels containing nifedipine. PH-sensitive beheviour of hydrogels in different pH medium was investigated.Methods To prepare sustained-release hydrogels of nifedipine with complex coacervation, the sustained release effect of hydrogels on nifedipine was studied by altering the concentration of chitosan and sodium alginate in the course of hydrogel preparation.Meanwhile, the dissolution rate of the prepared hydrogels was determined, and pH-sensitive beheviour in different pH medium was investigated.Results Sustained-release hydrogels containing nifedipine don’t dissociate in simulated gastric fluid, but in simulated intestinal fluid nifedipine dissociate completely in four hours.Conclusion The dissolution rate of the hydrogels was slower compared with the common tablets,