抗糖尿病药-胰岛素与口服降血糖药.pptVIP

抗糖尿病药－胰岛素与口服降血糖药(Antidiabetis Drugs－Insulin and Oral Antisiabetis Drugs);Overview;Overview;Overview;Overview;Overview;Overview;Substance Metabolic Disorder and Clinical Situation of Diabetic;Classification of Diabetes Mellitus (WHO 1998); ;Diabetes - Insulin;Diabetes – Insulin(synthesis, storage, secretion);Diabetes – Insulin(Biochemical Role);;Stage 1 Insulin was extracted from the glands of cows and pigs. (1920s) Stage 2 Convert pig insulin into human insulin by removing the one amino acid that distinguishes them and replacing it with the human version. ;Stage 3 Insert the human insulin gene into E. coli and culture the recombinant E.coli to produce insulin (trade name = Humulin?). Yeast is also used to produce insulin (trade name = Novolin?) (1987). ;Physiological disposition of insulin ;Types of insulin ;Insulin affects many organs: It stimulates skeletal muscle fibers. It stimulates liver cells. It acts on fat cells It inhibits production of certain enzyme. In each case, insulin triggers these effects by binding to the insulin receptor. ;The Pharmacological Action of Insulin;Who need insulin medicine?;Preparations and Clinical Use of insulin;;Insulin Regimens;Insulin Regimens;Insulin Regimens;Adverse Effects;Adverse Effects;Adverse Effects;Adverse Effects;Adverse Effects;Insulin Resistance (INR) ;Diabetes-Insulin Action Enhancers;The Action of Insulin Action Enhancers;Diabetes – Oral Medications;Oral Autidiabetic Drugs;Oral Autidiabetic Drugs;Sulfonylureas;The Mechanism of Action;The Pharmacological Effect of Sulfonylureas ;The Clinical Application of Sulfonylureas;Adverse Effects of Sulfonylureas;Drug Interactions;Biguanides;Mechanisms and Pharmacological Effects;Adverse Effects of Biguanides;Acarbose;The Indications of Acarbose;Adverse effects of Acarbose;Thanks!