Sequential injection spectrophotometric determination of levofloxacin ofloxacin and lomefloxacin.docVIP

 PAGE \* MERGEFORMAT 13 Sequential injection spectrophotometric determination of levofloxacin ofloxacin and lomefloxacin [Abstract] Based on levofloxacin, ofloxacin and lomefloxacin separately with Fe (III) role in the formation of yellow complexes, to establish a simple, rapid determination of drugs, levofloxacin, ofloxacin and lomefloxacin in the order injection spectrophotometric new approach. Discussion of the physical factors and chemical factors on the sensitivity of the method effects. Determination of levofloxacin, ofloxacin and lomefloxacin were working curve of the linear range of 10 ~ 250μ g/ml. Using molar ratio method and the determination of continuous transformation of the composition of complex, Fe (III) and drug the composition of the ratio of 1:2. The method used drugs levofloxacin, ofloxacin and lomefloxacin determination, and with reference to methods of control. [Keywords:] sequential injection analysis techniques; spectrophotometry; levofloxacin; ofloxacin; Lomefloxacin ABSTRACT A simple and rapid sequential injection spectrophotometric method for the determination of levofloxacin, ofloxacin and lomefloxacin in pharmaceutical preparation was described, based on the complexation reaction between the drug and Fe (III) in sulfuric acid solution. The various chemical and physical conditions that affected the reaction were studied. The calibration graphs were linear in the range of 10 ~ 250 μ g / ml for levofloxacin, ofloxacin and lomefloxacin. The composition of the complexes was found 1:2 Fe (III): drug by molar ratio method and Job ‘ s method of continuous variation. The method was successfully applied to the determination of levofloxacin, ofloxacin and lomefloxacin in pharmaceutical commercial formulations. The results obtained were compared with those of the reference methods. KEY WORDS Sequential injection analysis; Spectrophotometry; Levofloxacin; Ofloxacin; Lomefloxacin Levofloxacin, ofloxacin and lomefloxacin are three important s