Solvent evaporation method in the application of microspheres preparation and research progress of.docVIP

 PAGE \* MERGEFORMAT 26 Solvent evaporation method in the application of microspheres preparation and research progress of [Abstract] The microspheres prepared by solvent evaporation the basic principles of analysis of drugs prepared by solvent evaporation characteristics of micro-spheres, process and influencing factors, focusing on the solvent evaporation method of the four key steps: drugs, join, milk drops formation, solvent removed, the dry microspheres and recovery and expounded microspheres prepared by solvent evaporation technology and research progress of the status quo. [Keywords:] microspheres; solvent evaporation method; controlled-release formulations Fund Project: Guangdong Provincial Science and Technology Plan Project (53028) In recent years, scholars at home and abroad for natural polymer, biodegradable polymer, block polymer microspheres made of a large number of studies carried out to promote the micro-balls in the medical engineering and bio-technology widely used. For example, for embedded drugs and drug delivery of poly lactic acid microspheres, chitosan microspheres and albumin microspheres; for protein separation and purification, cell or cell culture embedding agarose and alginate microspheres ; for the insoluble drug injection block copolymer nanoparticles. Preparation of the polymer microspheres as the raw material most commonly used method is to first was prepared by O / W, W / O, W / O / W, O / W / O type emulsion, and then, depending on the use of a method of selecting the appropriate droplet solidified into microspheres. At present, the microspheres curing the physical and chemical methods are mainly three categories, namely, phase separation, spray drying and solvent evaporation method [1]. Microspheres prepared by spray drying operation is relatively simple, but the need for different polymer materials and drug selection of appropriate drying temperature, and the size of the microspheres is very difficult to control [2],