Sox9 gene therapy for intervertebral disc degeneration of the status quo.docVIP

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2017-05-05 发布于浙江
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Sox9 gene therapy for intervertebral disc degeneration of the status quo.doc

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Sox9 gene therapy for intervertebral disc degeneration of the status quo

Sox9 gene therapy for intervertebral disc degeneration of the status quo [Keywords:] degenerative disc disease Degenerative disc disease (disc degeneration disease, DDD) is a high incidence of disease and disability, often lead to neck and shoulder pain in waist and legs syndrome as the main clinical manifestations, according to data show that, DDD accounted for American Academy of Orthopedic Patients number of hospitalizations 1 / 3 of the above, the current DDD conventional treatment methods include medication, physical therapy, bed rest, steroid injections and surgical closure of treatment. However, these measures alone can improve the clinical signs of disease is not fundamentally slow down or terminate the process of degeneration. Therefore, further study of the mechanism of disc degeneration to try the molecular level, regulation and control of disc degeneration and thus for treatment of disc degeneration is very valuable. On the mechanism of DDD occurred in the past mainly focused on changes in disc biomechanics, disc’s own immune factors, inflammation, apoptosis, nutrient imbalance and intervertebral disc barriers a few. Recent studies have shown, Sox family, Sox9 gene may be related to disc degeneration has a close relationship, now the situation of their research are reviewed. A change in disc degeneration and collagen Disc contains a lot of collagen, which Ⅰ , Ⅱ collagen type I collagen is the most important, accounting for about 80% of the total, followed by collagen type Ⅵ , accounting for 10% ~ 20%. Under normal circumstances, Ⅰ collagen mainly in the outer fibrous ring, Ⅱ -type plastic principles mainly in the nucleus pulposus and cartilage end-plate. Type Ⅱ collagen, in the highest levels of the central disc to the edge is gradually reduced, while the principle of type Ⅰ glue just the opposite. But also the distribution of collagen in the disc is not within the age-related increase change. However, with the intervertebral disc degenerati