Targeted drug delivery system and its application in ophthalmology.docVIP

 PAGE \* MERGEFORMAT 37 Targeted drug delivery system and its application in ophthalmology 【Abstract】 by retrieving a large number of domestic and foreign literature, from targeted drug delivery system classification, role of the characteristics and applications in ophthalmology (prevention of after-cataract, prevention and treatment of age-related macular degeneration, eye cancer prevention, anti-inflammatory treatment, target sexual gene therapy) has done two to explore, study targeted drug delivery system for ophthalmic applications, the development of the status quo, found that targeted drug delivery system has great potential, with broader development and application prospects. Keywords: Eye targeted drug delivery Targeted drug delivery system (targeted drug delivery system, TDDS), also known as targeted drug delivery refers to the drug by local or systemic blood circulation while the concentrated position in the lesion tissues, organs, cells or cell within the new delivery systems. TDDS can be used as carriers of drugs selectively assembled on the role of the site to enhance the role of the parts of the drug in therapeutic concentrations fall from the sky low toxic side effects of purposes, in particular cytotoxic drugs, is considered suitable for anti-cancer drug formulations. TDDS require drug effects on the target tissue, target organ, target cells, and even inside the cell structure and require a certain concentration of the drug to stay for a long period of time in order to play a therapeutic effect, it is the ideal TDDS should have three elements: orientation accumulation to control drug release, biodegradable [1]. TDDS has a variety of clinical prevention and treatment of diseases demonstrated advantages, such as liver disease, stomach disease, colon, skin, brain and eye disease. This paper mainly on the targeted delivery of the classification, characteristics and the role of research in ophthalmology are reviewed.