Temperature-sensitive ligustrazine intraperitoneal sustained-release gel in situ preparation of Research and Evaluation.docVIP

 PAGE \* MERGEFORMAT 20 Temperature-sensitive ligustrazine intraperitoneal sustained-release gel in situ preparation of Research and Evaluation Authors: Yan Xu, Li-Qun Pan, Shi Yi, Jia XB, blue snow lotus, De-Xuan Chen 【Abstract】 Objective To prepare for Poloxamer 407 as the basic materials, the temperature-sensitive ligustrazine intraperitoneal sustained-release gel in situ to establish the temperature-sensitive ligustrazine intraperitoneal sustained-release gel in situ in vitro evaluation. Preparation of Poloxamer 407 (P-407) solutions of different concentrations were measured phase transition temperature, draw the viscosity - temperature curve and the temperature under the in vitro release rate determination, to choose for the pathological features of intra-abdominal adhesions TMP hydrochloride sustained-release gel in situ . Results The in vitro release experiment found that 40% P  407 in-situ gel and accessories 2% ~ 3% methyl cellulose (MC) The combination of hydrochloric acid in vitro release rate of TMP was significantly prolonged, the most in line with the requirement of experiment. Conclusions temperature-sensitive in situ ligustrazine intraperitoneal sustained-release gel has good in vitro release properties, temperature-sensitive adhesion properties and stability of the preparation method is simple and reproducible. Keywords: ligustrazine; in situ gel; Preparation Abstract: ObjectiveTo prepare temperature_sensitive situ gel of Ligustrazine Hydrochloride based on Poloxamer 407, which will be used in abdominal cavity, and establish its evaluation method in vitro.MethodsPrepare solution of Poloxamer 407 in different concentrations, measure their phase transition temperature, draw viscosity-temperature curve, determine drug release rate in vitro at the body temperature and choose the proper situ gel formulation according with the pathological characteristic of abdominal cavity adherence.ResultsThe optimizing formulation was